Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.47 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4019237 | 0.89 | KCNH2 (0.42) | KCNH2HRH3 | |
| SCHEMBL4011219 | 0.84 | KCNH2 (0.58) | KCNH2HRH3 | |
| SCHEMBL3634618 | 0.81 | KCNH2 (0.60) | KCNH2HRH3 | |
| SCHEMBL3790904 | 0.77 | SIGMAR1 (0.41) | HRH3 | |
| Fumaric Acid SCHEMBL3635098 | 0.75 | KCNH2 (0.53) | KCNH2HRH3 | |
| SCHEMBL1939632 | 0.69 | KCNH2 (0.79) | KCNH2HRH3 | |
| SCHEMBL1939182 | 0.69 | KCNH2 (0.79) | KCNH2HRH3 | |
| SCHEMBL27974591 | 0.68 | HTT (0.42) | KCNH2KCNJ1PTGS2 | |
| SCHEMBL10300269 | 0.63 | PTGS2 (0.62) | PTGS2 | |
| SCHEMBL7677302 | 0.63 | PTGS2 (0.62) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074086-A1 | BIPHENYL SULFONYL AND PHENYL-HETEROARYL SULFONYL MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008048609-A1 | BIPHENYL SULFONYL AND PHENYL-HETEROARYL SULFONYL MODULATORS OF THE HISTAMINE H3-RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2008-04-24 | — | — | WO | disclosed |