Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | THRB | P10828 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | NAAA | Q02083 | 1/20 | 0.54 |
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.50 |
| ▸ | PPARG | P37231 | 6/20 | 0.50 |
| ▸ | PPARD | Q03181 | 6/20 | 0.50 |
| ▸ | PPARA | Q07869 | 6/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | TLR2 | O60603 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | FABP4 | P15090 | 2/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.50 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.50 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL15512279 | 1.00 | CES2 (0.64) | CES2MEN1KMT2ATHRBHTT | |
| Bicarbonate SCHEMBL8198778 | 1.00 | CES2 (0.64) | CES2MEN1KMT2ATHRBHTT | |
| Bicarbonate SCHEMBL29081021 | 0.97 | CES2 (0.61) | CES2MEN1KMT2ATHRBHTT | |
| Acetic Acid SCHEMBL537713 | 0.92 | CES2 (0.68) | CES2MEN1KMT2ATHRBHTT | |
| Acetic Acid SCHEMBL2863329 | 0.92 | CES2 (0.68) | CES2MEN1KMT2ATHRBHTT | |
| Acetic Acid SCHEMBL2400937 | 0.92 | CES2 (0.68) | CES2MEN1KMT2ATHRBHTT | |
| Acetic Acid SCHEMBL3139068 | 0.92 | CES2 (0.68) | CES2MEN1KMT2ATHRBHTT | |
| Acetic Acid SCHEMBL138223 | 0.92 | CES2 (0.68) | CES2MEN1KMT2ATHRBHTT | |
| Acetic Acid SCHEMBL4930252 | 0.92 | CES2 (0.68) | CES2MEN1KMT2ATHRBHTT | |
| Acetic Acid SCHEMBL3426392 | 0.92 | CES2 (0.68) | CES2MEN1KMT2ATHRBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104356575-A | Preparing method of matte low-temperature plastic alloy | QINGDAO TONGSHENGTONG RUBBER & PLASTIC CO LTD | 2015-02-18 | — | — | CN | disclosed |