Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.56 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30914586 | 0.91 | HTR6 (0.66) | HTR6SMPD1HDAC8HDAC6HDAC1 | |
| SCHEMBL6086778 | 0.91 | HTR6 (0.66) | HTR6SMPD1HDAC8HDAC6HDAC1 | |
| SCHEMBL257765 | 0.76 | HTR6 (0.70) | HTR6HDAC8HDAC6HDAC1HDAC2 | |
| SCHEMBL2580966 | 0.76 | HTR6 (0.70) | HTR6HDAC8HDAC6HDAC1HDAC2 | |
| SCHEMBL28886142 | 0.75 | HTR2A (0.57) | HTR6HDAC8HDAC6HDAC1HDAC2 | |
| SCHEMBL30218812 | 0.75 | KMT2A (0.63) | HTR6HDAC8HDAC6HDAC1HDAC2 | |
| SCHEMBL6087249 | 0.75 | KMT2A (0.63) | HTR6HDAC8HDAC6HDAC1HDAC2 | |
| SCHEMBL7548794 | 0.75 | ALDH1A1 (0.60) | HTR6HDAC8HDAC6HDAC1HDAC2 | |
| SCHEMBL29509279 | 0.75 | HTR6 (0.73) | HTR6HDAC8HDAC6HDAC1HDAC2 | |
| SCHEMBL31021 | 0.75 | HTR6 (0.73) | HTR6HDAC8HDAC6HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104130175-A | Different-position substituted indolone derivatives and application thereof | UNIV TIANJIN SCIENCE & TECH | 2014-11-05 | — | — | CN | claimed |
| CN-104130175-A | Different-position substituted indolone derivatives and application thereof | UNIV TIANJIN SCIENCE & TECH | 2014-11-05 | — | — | CN | disclosed |