Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR3 | P46089 | 1/20 | 0.64 |
| ▸ | BCHE | P06276 | 2/20 | 0.62 |
| ▸ | ACHE | P22303 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | CASP6 | P55212 | 1/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.50 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.50 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11808516 | 0.89 | BCHE (0.67) | GPR3BCHEACHEKDM4EMEN1 | |
| SCHEMBL1538292 | 0.88 | GPR3 (0.64) | GPR3BCHEACHEKDM4EMEN1 | |
| SCHEMBL11378517 | 0.85 | HTT (0.57) | GPR3BCHEACHEKDM4EMEN1 | |
| SCHEMBL3423941 | 0.81 | GPR3 (0.80) | GPR3BCHEACHEKDM4EMEN1 | |
| SCHEMBL20384979 | 0.80 | ACHE (0.57) | BCHEACHEKDM4EMEN1KMT2A | |
| SCHEMBL3875311 | 0.80 | GPR3 (0.64) | GPR3KDM4EMEN1KMT2AMAPT | |
| SCHEMBL5713524 | 0.80 | MEN1 (0.43) | GPR3BCHEACHEKDM4EMEN1 | |
| SCHEMBL29461528 | 0.80 | GPR3 (1.00) | GPR3BCHEACHEKDM4EMEN1 | |
| SCHEMBL29321 | 0.80 | GPR3 (1.00) | GPR3BCHEACHEKDM4EMEN1 | |
| SCHEMBL5795432 | 0.79 | MAPT (0.65) | KDM4EMEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104231023-B | Tricyclic fused heterocycle nucleoside phosphoramidate compound, preparation method and application | 南京汇诚制药有限公司 | 2019-02-05 | — | — | CN | disclosed |
| CN-104231023-A | Tricyclic fused-heterocyclic nucleoside phosphoramidate compound and preparation method and applications of tricyclic fused-heterocyclic nucleoside phosphoramidate compound | NANJING SANHOME PHARMACEUTICAL CO LTD | 2014-12-24 | — | — | CN | disclosed |