Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3786077 | 1.00 | NR1H2 (0.48) | NR1H2NR1H3PTPN1MMP2ANPEP | |
| SCHEMBL2278207 | 1.00 | NR1H2 (0.48) | NR1H2NR1H3PTPN1MMP2ANPEP | |
| SCHEMBL30401835 | 0.98 | NR1H2 (0.47) | NR1H2NR1H3PTPN1MMP2ANPEP | |
| SCHEMBL2253790 | 0.85 | MMP2 (0.43) | NR1H2NR1H3PTPN1MMP2ANPEP | |
| SCHEMBL18589421 | 0.85 | PEPD (0.47) | NR1H2NR1H3PTPN1MMP2ANPEP | |
| SCHEMBL24645309 | 0.85 | PEPD (0.47) | NR1H2NR1H3PTPN1MMP2ANPEP | |
| SCHEMBL6122335 | 0.85 | MMP2 (0.43) | NR1H2NR1H3PTPN1MMP2ANPEP | |
| SCHEMBL6848252 | 0.85 | MMP2 (0.43) | NR1H2NR1H3PTPN1MMP2ANPEP | |
| SCHEMBL3789795 | 0.85 | CYP3A4 (0.53) | NR1H2NR1H3PTPN1MMP2ANPEP | |
| SCHEMBL882756 | 0.85 | PEPD (0.47) | NR1H2NR1H3PTPN1MMP2ANPEP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240208968-A1 | ALPHA V BETA 6 AND ALPHA V BETA 1 INTEGRIN INHIBITORS AND USES THEREOF | DICE MOLECULES SV, INC. | 2024-06-27 | — | — | US | disclosed |
| EP-2847185-B1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2016-11-16 | — | — | EP | disclosed |
| US-9144239-B2 | Macrocyclic picolinamides as fungicides | DOW AGROSCIENCES LLC (US) | 2015-09-29 | — | — | US | disclosed |
| EP-2847185-A2 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | Dow AgroSciences LLC (US) | 2015-03-18 | — | — | EP | disclosed |
| US-20140275171-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC | 2014-09-18 | — | — | US | disclosed |
| US-8785479-B2 | Macrocyclic picolinamides as fungicides | DOW AGROSCIENCES, LLC. (US) | 2014-07-22 | — | — | US | disclosed |
| WO-2013169662-A2 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2013-11-14 | — | — | WO | disclosed |
| US-20130296375-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | DOW AGROSCIENCES LLC (US) | 2013-11-07 | — | — | US | disclosed |
| WO-2010091104-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | EXELIXIS, INC. (US) | 2010-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275171-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | FKBP14, FKBP2, CYP51A1 | NR1H2 3105/4885NR1H3 3405/4885PTPN1 130/4885 |
| US-20240208968-A1 | ALPHA V BETA 6 AND ALPHA V BETA 1 INTEGRIN INHIBITORS AND USES THEREOF | ITGB1, ITGA1, ITGAV | NR1H2 2279/4885NR1H3 2251/4885PTPN1 1542/4885 |
| US-20130296375-A1 | MACROCYCLIC PICOLINAMIDES AS FUNGICIDES | FKBP14, FKBP2, CYP51A1 | NR1H2 3105/4885NR1H3 3405/4885PTPN1 130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.