Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GALR3 | O60755 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2794482 | 0.84 | LMNA (0.46) | THRBTSHRSMN1; SMN2LMNAGALR3 | |
| SCHEMBL440616 | 0.81 | TSHR (0.45) | THRBTSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL4616679 | 0.81 | MAPT (0.43) | THRBTSHRALDH1A1SMN1; SMN2LMNA | |
| Ammonia Solution, Strong SCHEMBL27784925 | 0.79 | TSHR (0.43) | THRBTSHRALDH1A1 | |
| SCHEMBL28330589 | 0.79 | TSHR (0.41) | THRBTSHRALDH1A1SMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL27513614 | 0.78 | THRB (0.36) | THRBTSHRALDH1A1SMN1; SMN2LMNA | |
| Methylamine SCHEMBL27627991 | 0.77 | TSHR (0.42) | THRBTSHRALDH1A1 | |
| SCHEMBL27552593 | 0.76 | TSHR (0.35) | THRBTSHRALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4108307 | 0.76 | TSHR (0.41) | THRBTSHRALDH1A1 | |
| SCHEMBL159608 | 0.76 | TSHR (0.41) | THRBTSHRALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168282-A1 | DISPERSION COMPRISING INORGANIC PARTICLES, WATER, AND AT LEAST ONE POLYMERIC ADDITIVE | EVONIK ROEHM GMBH (DE) | 2010-07-01 | — | — | US | disclosed |