Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.44 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.42 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | RXRB | P28702 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5104447 | 0.84 | PLA2G2A (0.54) | PLA2G4BTP53TSHRPLA2G2A | |
| SCHEMBL2799354 | 0.83 | PARP10 (0.50) | PTGS2ALDH1A1MAPK1FFAR1FFAR4 | |
| SCHEMBL18186540 | 0.83 | PTGS2 (0.40) | PTGS2KDM4EFFAR1FFAR4SMN1; SMN2 | |
| SCHEMBL1583340 | 0.81 | PLA2G2A (0.64) | PLA2G4BTP53TSHRPLA2G2A | |
| SCHEMBL8640999 | 0.81 | PLA2G2A (0.64) | PLA2G4BTP53TSHRPLA2G2A | |
| SCHEMBL4850809 | 0.78 | KDM4E (0.50) | PTGS2PLA2G4BRXRARXRBHSD17B10 | |
| SCHEMBL29196803 | 0.78 | SLC5A1 (0.50) | PLA2G4BRXRARXRBHSD17B10KDM4E | |
| SCHEMBL1646977 | 0.78 | POLB (0.45) | PTGS2RXRAKDM4EALDH1A1MAPK1 | |
| SCHEMBL13366264 | 0.77 | RARA (0.55) | CAMKK1CAMKK2HSD17B10KDM4EALDH1A1 | |
| SCHEMBL15086897 | 0.75 | NQO1 (0.44) | PTGS2HSD17B10KDM4EALDH1A1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168143-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB | 2010-07-01 | — | — | US | disclosed |
| EP-1979344-A2 | N-(2,3-DIFLUOROPHENYL)-2-[4-({7-METHOXY-5-[(2R)-PIPERIDIN.-2-YLMETHOXY]QUINAZOLIN-4-YL}AMINO)-1H-PYRAZOL-1-YL]ACETAMIDE AND N-(2,3-DIFLUOROPHENYL)-2-[4-({7-ETHOXY-5-[(2R)-PIPERIDIN.-2-YLMETHOXY]QUINAZOLIN-4-YL}AMINO)-1H-PYRAZOL-1-YL]ACETAMIDE FOR USE IN THE TREATMENT OF DISEASE | AstraZeneca AB (SE) | 2008-10-15 | — | — | EP | disclosed |
| US-20080194556-A1 | Quinazolines and Their Use as Aurora Kinase Inhibitors | ASTRAZENECA AB (SE) | 2008-08-14 | — | — | US | disclosed |
| EP-1888572-A1 | QUINAZOLINES AND THEIR USE AS AURORA KINASE INHIBITORS | AstraZeneca AB (SE) | 2008-02-20 | — | — | EP | disclosed |
| WO-2007083096-A2 | N- (2, 3-DIFLUOROPHENYL) -2- [4- ( {7-METHOXY-5- [ (2R) -PIPERIDIN. -2-YLMETHOXY] QUINAZOLI N-4-YL}AMINO) -LH-PYRAZOL-1-YL] ACETAMIDE AND N- (2, 3 -D I FLUORO PHENYL) -2- [4- ( {7-ETHOXY-5- [ (2R) -PIPERIDIN. -2-YLMETHOXY] QUINAZOLIN | ASTRAZENECA AB (SE) | 2007-07-26 | — | — | WO | disclosed |
| WO-2006129064-A1 | QUINAZOLINES AND THEIR USE AS AURORA KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-12-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194556-A1 | Quinazolines and Their Use as Aurora Kinase Inhibitors | AURKA, AURKC, AURKB | PTGS2 3754/4885PLA2G4B 3006/4885CAMKK1 726/4885 |
| US-20100168143-A1 | QUINAZOLINE DERIVATIVES | CCNI, NQO2, MKI67 | PTGS2 959/4885PLA2G4B 4212/4885CAMKK1 2995/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.