Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SI | P14410 | 1/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27991671 | 0.79 | POLB (0.42) | MGAMGAASIMGAM2HTT | |
| SCHEMBL5166833 | 0.78 | P2RX3 (0.45) | MGAMGAASIMGAM2CYP3A4 | |
| SCHEMBL2540155 | 0.75 | LMNA (0.40) | MGAMGAASIMGAM2MTNR1A | |
| SCHEMBL5042406 | 0.75 | LMNA (0.41) | MGAMGAASIMGAM2MTNR1A | |
| SCHEMBL27661831 | 0.75 | GAA (0.40) | MGAMGAASIMGAM2LMNA | |
| SCHEMBL27993308 | 0.74 | ALDH1A1 (0.38) | MGAMGAASIMGAM2MTNR1A | |
| SCHEMBL2545081 | 0.74 | LMNA (0.39) | MGAMGAASIMGAM2MTNR1A | |
| SCHEMBL15676827 | 0.74 | LMNA (0.39) | MGAMGAASIMGAM2MTNR1A | |
| SCHEMBL27789213 | 0.73 | MGAM (0.43) | MGAMGAASIMGAM2MTNR1A | |
| SCHEMBL28821875 | 0.72 | CES2 (0.35) | RAB9AALDH1A1PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104349777-A | Compounds for the treatment of spinal muscular atrophy | PTC THERAPEUTICS INC | 2015-02-11 | — | — | CN | disclosed |