Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.51 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CDK8 | P49336 | 4/20 | 0.48 |
| ▸ | MET | P08581 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinoline SCHEMBL27994190 | 0.83 | AXL (0.51) | AXLNUDT1NR4A2ALDH1A1CDK8 | |
| SCHEMBL294108 | 0.83 | CDK8 (0.55) | AXLNUDT1NR4A2CDK8PIK3CD | |
| Quinoline SCHEMBL20292966 | 0.81 | AXL (0.78) | AXLNUDT1NR4A2ALDH1A1CDK8 | |
| Quinoline SCHEMBL27777493 | 0.81 | AHR (0.62) | AXLNUDT1NR4A2ALDH1A1KDR | |
| Quinoline SCHEMBL28859524 | 0.80 | AXL (0.75) | AXLNUDT1NR4A2ALDH1A1CDK8 | |
| Quinoline SCHEMBL28826923 | 0.78 | NR4A2 (0.63) | AXLNUDT1NR4A2ALDH1A1 | |
| Quinoline SCHEMBL28816675 | 0.75 | ALDH1A1 (0.63) | AXLNUDT1NR4A2ALDH1A1CDK1 | |
| Quinoline SCHEMBL28292512 | 0.75 | ALDH1A1 (0.63) | AXLNUDT1NR4A2ALDH1A1CDK1 | |
| Quinoline SCHEMBL843861 | 0.75 | ALDH1A1 (0.63) | AXLNUDT1NR4A2ALDH1A1CDK1 | |
| Quinoline SCHEMBL28073739 | 0.75 | ALDH1A1 (0.63) | AXLNUDT1NR4A2ALDH1A1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106279156-A | A kind of synthetic method of 5 chlorine 7 azaindoles | 叶芳 | 2017-01-04 | — | — | CN | claimed |
| CN-106279156-A | A kind of synthetic method of 5 chlorine 7 azaindoles | 叶芳 | 2017-01-04 | — | — | CN | disclosed |