Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC5R | P33032 | 2/20 | 0.64 |
| ▸ | MC3R | P41968 | 2/20 | 0.64 |
| ▸ | MC1R | Q01726 | 1/20 | 0.64 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.64 |
| ▸ | HTR2A | P28223 | 3/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | HTR2C | P28335 | 2/20 | 0.60 |
| ▸ | MPO | P05164 | 1/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | HTR1D | P28221 | 1/20 | 0.60 |
| ▸ | HTR1B | P28222 | 1/20 | 0.60 |
| ▸ | HTR7 | P34969 | 1/20 | 0.60 |
| ▸ | CTSK | P43235 | 1/20 | 0.60 |
| ▸ | HTR6 | P50406 | 1/20 | 0.60 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.60 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5513944 | 0.81 | MAPT (0.57) | ADORA2AHTR2ACYP3A4HTR2CMPO | |
| SCHEMBL4985934 | 0.78 | HTR2A (0.77) | MC5RMC3RMC1RHTR2ACYP3A4 | |
| SCHEMBL5598639 | 0.78 | HTR2A (0.61) | MC5RMC3RMC1RHTR2ACYP3A4 | |
| SCHEMBL13668031 | 0.78 | HTR2A (0.61) | MC5RMC3RMC1RHTR2ACYP3A4 | |
| SCHEMBL4404041 | 0.78 | HTR2A (0.61) | MC5RMC3RMC1RHTR2ACYP3A4 | |
| SCHEMBL7615214 | 0.78 | ADORA2A (0.53) | ADORA2AHTR2ACYP3A4HTR2CMPO | |
| Tryptamine SCHEMBL8714244 | 0.75 | HTR2A (1.00) | MC5RMC3RMC1RHTR2ACYP3A4 | |
| Tryptophol SCHEMBL29364545 | 0.75 | HTR2A (0.67) | MC5RMC3RMC1RHTR2ACYP3A4 | |
| Tryptophol SCHEMBL196126 | 0.75 | HTR2A (0.67) | MC5RMC3RMC1RHTR2ACYP3A4 | |
| Tryptamine SCHEMBL29373222 | 0.75 | HTR2A (1.00) | MC5RMC3RMC1RHTR2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9296697-B2 | Hetaryl-substituted guanidine compounds and use thereof as binding partners for 5-HT5-receptors | ABBOTT LABORATORIES (US) | 2016-03-29 | — | — | US | disclosed |
| US-20100184787-A1 | Heataryl-substituted guanidine compounds and use thereof as binding partners for 5-ht5-receptors | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2010-07-22 | — | — | US | disclosed |
| WO-2000009115-A1 | GRP RECEPTOR LIGANDS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-02-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184787-A1 | Heataryl-substituted guanidine compounds and use thereof as binding partners for 5-ht5-receptors | HTR5A, HTR2C, HTR1E | MC5R 38/4885MC3R 491/4885MC1R 400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.