Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Glutethimide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 18/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.61 |
| ▸ | CYP11A1 | P05108 | 1/20 | 0.61 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.61 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aminoglutethimide SCHEMBL27862969 | 0.89 | CYP19A1 (0.80) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| Glutethimide SCHEMBL113708 | 0.88 | CYP19A1 (0.72) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| Glutethimide SCHEMBL21119240 | 0.88 | CYP19A1 (0.72) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| Glutethimide SCHEMBL113709 | 0.88 | CYP19A1 (0.72) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| Glutethimide SCHEMBL28781825 | 0.84 | CYP19A1 (0.63) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| Glutethimide SCHEMBL16041753 | 0.83 | CYP19A1 (0.59) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| SCHEMBL2907489 | 0.80 | CYP19A1 (0.70) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| SCHEMBL21834848 | 0.78 | CYP19A1 (0.63) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| SCHEMBL6246501 | 0.77 | CYP19A1 (0.52) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| Phenytoin SCHEMBL11881406 | 0.77 | CYP19A1 (0.58) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107198792-A | Biodegradable support meanss | Q3 医疗设备有限公司 | 2017-09-26 | — | — | CN | disclosed |
| CN-104220103-B | biodegradable support device | Q3医疗设备有限公司 | 2017-03-29 | — | — | CN | disclosed |
| CN-104220103-A | biodegradable support device | EVENTIONS LLC | 2014-12-17 | — | — | CN | disclosed |