Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Glutethimide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 18/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.59 |
| ▸ | CYP11A1 | P05108 | 1/20 | 0.59 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glutethimide SCHEMBL21119240 | 0.89 | CYP19A1 (0.72) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| Glutethimide SCHEMBL113709 | 0.89 | CYP19A1 (0.72) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| Glutethimide SCHEMBL113708 | 0.89 | CYP19A1 (0.72) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| Aminoglutethimide SCHEMBL159173 | 0.89 | CYP19A1 (0.78) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| Glutethimide SCHEMBL28781825 | 0.85 | CYP19A1 (0.63) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| Glutethimide SCHEMBL27996221 | 0.83 | CYP19A1 (0.61) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| Phenytoin SCHEMBL11881406 | 0.78 | CYP19A1 (0.58) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| SCHEMBL21834848 | 0.76 | CYP19A1 (0.63) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| SCHEMBL16509358 | 0.76 | CYP19A1 (0.75) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 | |
| SCHEMBL2907489 | 0.76 | CYP19A1 (0.70) | CYP19A1CYP3A4CYP17A1CYP11A1TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9358211-B2 | Stealth polymeric particles for delivery of bioactive or diagnostic agents | HOWARD UNIVERSITY (US) | 2016-06-07 | — | — | US | disclosed |
| US-20140274929-A1 | Stealth Polymeric Particles For Delivery Of Bioactive Or Diagnostic Agents | HOWARD UNIVERSITY (US) | 2014-09-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140274929-A1 | Stealth Polymeric Particles For Delivery Of Bioactive Or Diagnostic Agents | SSTR5, PLA2G3, SSTR3 | CYP19A1 2234/4885CYP3A4 4612/4885CYP17A1 3187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.