Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 2/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | AGXT | P21549 | 1/20 | 0.37 |
| ▸ | CHKA | P35790 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27997453 | 0.83 | AGXT (0.47) | HRH4NCF1AGXTHTR6SIGMAR1 | |
| SCHEMBL27997451 | 0.76 | HTR6 (0.49) | HRH4NCF1AGXTHTR6 | |
| SCHEMBL27997675 | 0.75 | HTR6 (0.46) | HRH4NCF1AGXTHTR6 | |
| SCHEMBL27997677 | 0.74 | AGXT (0.43) | HRH4NCF1SMN1; SMN2AGXTDRD4 | |
| SCHEMBL270284 | 0.73 | ALDH1A1 (0.59) | USP2SMN1; SMN2CHKAHPGDALOX15 | |
| SCHEMBL27997678 | 0.73 | HTR6 (0.46) | NCF1AGXTHTR6GAA | |
| SCHEMBL27997452 | 0.73 | HTR6 (0.46) | HRH4NCF1AGXTALOX15DRD4 | |
| SCHEMBL17911875 | 0.68 | ALDH1A1 (0.46) | HRH4SMN1; SMN2SIGMAR1GALR3GAA | |
| SCHEMBL348623 | 0.67 | TSHR (0.52) | SMN1; SMN2SIGMAR1 | |
| SCHEMBL3578032 | 0.66 | NPC1 (0.42) | SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104271576-A | Pyridopyrimidinone inhibitors of kinases | ABBVIE INC | 2015-01-07 | — | — | CN | claimed |
| CN-104271576-A | Pyridopyrimidinone inhibitors of kinases | ABBVIE INC | 2015-01-07 | — | — | CN | disclosed |