Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | AGXT | P21549 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27997675 | 0.87 | HTR6 (0.46) | HTR6KDM4EHRH4HRH3MAPT | |
| SCHEMBL27997677 | 0.86 | AGXT (0.43) | HTR6KDM4EALDH1A1HRH4HRH3 | |
| SCHEMBL27997678 | 0.85 | HTR6 (0.46) | HTR6HTTGAAMAPTAGXT | |
| SCHEMBL27997453 | 0.82 | AGXT (0.47) | HTR6HRH4HRH3AGXTHTR3A | |
| SCHEMBL14059902 | 0.77 | CYP1A2 (0.47) | HTR6ALDH1A1HRH4AGXTDRD2 | |
| SCHEMBL27943408 | 0.76 | DRD2 (0.45) | HTR6KDM4EALDH1A1HTTGAA | |
| SCHEMBL27997451 | 0.75 | HTR6 (0.49) | HTR6KDM4EALDH1A1HRH4HRH3 | |
| SCHEMBL27997446 | 0.73 | SMO (0.41) | HTR6HRH4GAAAGXTDRD4 | |
| SCHEMBL27943398 | 0.72 | NCF1 (0.46) | KDM4EALDH1A1HTTHRH3GAA | |
| SCHEMBL14060358 | 0.69 | HRH4 (0.47) | ALDH1A1HTTHRH4GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104271576-A | Pyridopyrimidinone inhibitors of kinases | ABBVIE INC | 2015-01-07 | — | — | CN | claimed |
| CN-104271576-A | Pyridopyrimidinone inhibitors of kinases | ABBVIE INC | 2015-01-07 | — | — | CN | disclosed |