Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 3/20 | 0.46 |
| ▸ | AGXT | P21549 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NCF1 | P14598 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | KHK | P50053 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27997452 | 0.87 | HTR6 (0.46) | HTR6AGXTHRH4HRH3HTR3A | |
| SCHEMBL27997678 | 0.87 | HTR6 (0.46) | HTR6AGXTHTR3ANCF1ADRA2C | |
| SCHEMBL27997453 | 0.85 | AGXT (0.47) | HTR6AGXTHRH4HRH3HTR3A | |
| SCHEMBL27997451 | 0.80 | HTR6 (0.49) | HTR6AGXTHRH4HRH3KDM4E | |
| SCHEMBL27997677 | 0.77 | AGXT (0.43) | HTR6AGXTHRH4HRH3HTR3A | |
| SCHEMBL27997446 | 0.75 | SMO (0.41) | HTR6AGXTHRH4NCF1 | |
| SCHEMBL27943398 | 0.74 | NCF1 (0.46) | AGXTHRH3HTR3AKDM4ENCF1 | |
| SCHEMBL14059902 | 0.69 | CYP1A2 (0.47) | HTR6AGXTHRH4HTR3ALMNA | |
| SCHEMBL14060813 | 0.67 | MAP4K1 (0.43) | HTR6AGXTHRH4HTR3AADRA2C | |
| SCHEMBL27943408 | 0.67 | DRD2 (0.45) | HTR6AGXTHTR3AKDM4EADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104271576-A | Pyridopyrimidinone inhibitors of kinases | ABBVIE INC | 2015-01-07 | — | — | CN | claimed |
| CN-104271576-A | Pyridopyrimidinone inhibitors of kinases | ABBVIE INC | 2015-01-07 | — | — | CN | disclosed |