SCHEMBL2800429

SCHEMBL2800429

BrCCCC#Cc1cc(C#CCCCBr)c(C#CCCCBr)cc1C#CCCCBr

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.39
CHRNB4 P30926 2/20 0.39
CHRNA3 P32297 2/20 0.39
CHRNA7 P36544 2/20 0.39
CHRNA4 P43681 2/20 0.39
CHRNA10 Q9GZZ6 2/20 0.39
CHRNA9 Q9UGM1 2/20 0.39
KDM4E B2RXH2 1/20 0.33
ALDH1A1 P00352 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
MAPT P10636 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
PTPN1 P18031 1/20 0.32
PTPN11 Q06124 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2799266 0.89 KDM4E (0.43) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL2175823 0.81 CYP3A4 (0.47) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL1878352 0.80 CHRNA7 (0.39) CHRNA7CHRNA10CHRNA9
SCHEMBL2797723 0.75 KDM4E (0.50) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL2179678 0.73 HTR2C (0.38) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL12490670 0.72 KDM4E (0.40) CHRNB2CHRNB4CHRNA3CHRNA7CHRNA4
SCHEMBL9670354 0.71 MEN1 (0.43) KDM4EALDH1A1CYP1A2CYP3A4MAPT
SCHEMBL15242149 0.70 CHRNA7 (0.33) CHRNA7CHRNA10CHRNA9
SCHEMBL2180140 0.70 CYP1A2 (0.50) CHRNA7CHRNA10CHRNA9KDM4EALDH1A1
SCHEMBL14465889 0.68

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8629163-B2 Tetrakis-quaternary ammonium salts and methods for modulating neuronal nicotinic acteylcholine receptors UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2014-01-14 US disclosed
US-8629163-B2 Tetrakis-quaternary ammonium salts and methods for modulating neuronal nicotinic acteylcholine receptors UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2014-01-14 US disclosed
US-8629163-B2 Tetrakis-quaternary ammonium salts and methods for modulating neuronal nicotinic acteylcholine receptors UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2014-01-14 US disclosed
US-20130231366-A1 Use of a Novel Alpha-7 Nachr Antagonist to Suppress Pathogenic Signal Transduction in Cancer and Aids UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2013-09-05 US disclosed
US-20130231366-A1 Use of a Novel Alpha-7 Nachr Antagonist to Suppress Pathogenic Signal Transduction in Cancer and Aids UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2013-09-05 US disclosed
US-20130231366-A1 Use of a Novel Alpha-7 Nachr Antagonist to Suppress Pathogenic Signal Transduction in Cancer and Aids UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2013-09-05 US disclosed
US-20100179186-A1 USE OF A NOVEL ALPHA-7 nAChR ANTAGONIST TO SUPPRESS PATHOGENIC SIGNAL TRANSDUCTION IN CANCER AND AIDS UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2010-07-15 US disclosed
US-20100179186-A1 USE OF A NOVEL ALPHA-7 nAChR ANTAGONIST TO SUPPRESS PATHOGENIC SIGNAL TRANSDUCTION IN CANCER AND AIDS UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2010-07-15 US disclosed
US-20100173937-A1 USE OF TETRAKIS-QUATERNARY AMMONIUM SALTS AS PAIN MODULATING AGENTS UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2010-07-08 US disclosed
US-20100173937-A1 USE OF TETRAKIS-QUATERNARY AMMONIUM SALTS AS PAIN MODULATING AGENTS UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2010-07-08 US disclosed
US-20090143424-A1 TETRAKIS-QUATERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACTEYLCHOLINE RECEPTORS UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2009-06-04 US disclosed
US-20090143424-A1 TETRAKIS-QUATERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACTEYLCHOLINE RECEPTORS UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) 2009-06-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100179186-A1 USE OF A NOVEL ALPHA-7 nAChR ANTAGONIST TO SUPPRESS PATHOGENIC SIGNAL TRANSDUCTION IN CANCER AND AIDS CHRNA7, CHRNG, CHRNE CHRNB2 16/4885CHRNB4 15/4885CHRNA3 14/4885
US-20130231366-A1 Use of a Novel Alpha-7 Nachr Antagonist to Suppress Pathogenic Signal Transduction in Cancer and Aids CHRNA7, CHRNG, CHRNE CHRNB2 16/4885CHRNB4 15/4885CHRNA3 14/4885
US-20100173937-A1 USE OF TETRAKIS-QUATERNARY AMMONIUM SALTS AS PAIN MODULATING AGENTS CACNA1I, TRPA1, KCNN3 CHRNB2 353/4885CHRNB4 373/4885CHRNA3 233/4885
US-20090143424-A1 TETRAKIS-QUATERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACTEYLCHOLINE RECEPTORS CHRNA3, CHRNA2, CHRNA4 CHRNB2 11/4885CHRNB4 12/4885CHRNA3 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.