Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 2/20 | 0.48 |
| ▸ | SGK1 | O00141 | 1/20 | 0.45 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.44 |
| ▸ | TDO2 | P48775 | 7/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | ASH1L | Q9NR48 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28005054 | 0.87 | ASH1L (0.50) | SGK1TDO2ASH1L | |
| SCHEMBL22158783 | 0.80 | IMPDH2 (0.54) | IMPDH2TDO2ASH1LMMP2PRKAB2 | |
| SCHEMBL122574 | 0.77 | MMP2 (0.56) | CLK1SGK1IMPDH2ASH1LMMP2 | |
| SCHEMBL27698578 | 0.77 | NR4A2 (0.58) | CLK1SGK1IMPDH2TDO2ASH1L | |
| SCHEMBL10397390 | 0.72 | HSD17B1 (0.59) | MMP2HSD17B1 | |
| SCHEMBL21734392 | 0.71 | HSD17B1 (0.53) | HSD17B1 | |
| SCHEMBL13211664 | 0.71 | MAPT (0.50) | SGK1HSD17B1 | |
| SCHEMBL15651984 | 0.70 | NR4A2 (0.41) | PLGPLAU | |
| SCHEMBL13323653 | 0.70 | NPSR1 (0.42) | — | |
| SCHEMBL255900 | 0.70 | PRKAB2 (0.56) | SGK1IMPDH2TDO2IDO1ASH1L |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102036953-B | Arylsulfonamide-based matrix metalloprotease inhibitors | NOVARTIS AG | 2015-05-06 | — | — | CN | claimed |
| CN-102036953-B | Arylsulfonamide-based matrix metalloprotease inhibitors | NOVARTIS AG | 2015-05-06 | — | — | CN | disclosed |