Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 2/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | CTSB | P07858 | 1/20 | 0.49 |
| ▸ | CTSH | P09668 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CETP | P11597 | 3/20 | 0.45 |
| ▸ | PPARG | P37231 | 5/20 | 0.45 |
| ▸ | PPARA | Q07869 | 5/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL28004213 | 0.90 | NPC1 (0.47) | CTSKCTSLCTSBCTSHTSHR | |
| SCHEMBL15899161 | 0.83 | ACACB (0.47) | TSHRL3MBTL1PPARGPPARAPPARD | |
| SCHEMBL2701708 | 0.82 | SIGMAR1 (0.48) | — | |
| SCHEMBL8072578 | 0.82 | PPARA (0.59) | PPARGPPARAPPARD | |
| SCHEMBL1839950 | 0.81 | ESR1 (0.47) | TSHRALDH1A1CYP3A4MAPK1 | |
| SCHEMBL10512424 | 0.81 | MEN1 (0.46) | TSHRTDP1L3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL8163169 | 0.81 | TP53 (0.58) | TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL3275777 | 0.80 | LTA4H (0.46) | TSHRTDP1L3MBTL1ALDH1A1CYP3A4 | |
| SCHEMBL8150638 | 0.80 | L3MBTL1 (0.47) | TSHRTDP1L3MBTL1MEN1KMT2A | |
| SCHEMBL7759621 | 0.79 | CSNK1E (0.47) | TSHRTDP1L3MBTL1ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105837714-B | The manufacturing method of solid catalyst component for olefin polymerization, the manufacturing method of polymerization of olefines catalyst and olefin polymer | 东邦钛株式会社 | 2018-07-20 | — | — | CN | disclosed |
| CN-105008407-B | Process for producing propylene block copolymer | 东邦钛株式会社 | 2018-03-06 | — | — | CN | disclosed |
| CN-104822712-B | Solid catalyst component for polymerizing olefin, catalyst for polymerizing olefin, and method for producing polymerized olefin | 东邦钛株式会社 | 2018-02-23 | — | — | CN | disclosed |
| CN-104470953-B | Process for producing solid catalyst component for olefin polymerization, catalyst for olefin polymerization, and process for producing olefin polymer | 东邦钛株式会社 | 2017-11-14 | — | — | CN | disclosed |
| CN-106414515-A | Solid catalyst component for use in polymerization of olefins, method for producing same, catalyst for use in polymerization of olefins, and method for producing olefin polymer | 东邦钛株式会社 | 2017-02-15 | — | — | CN | disclosed |
| CN-105837714-A | METHOD FOR PRODUCING SOLID CATALYST COMPONENT FOR USE IN POLYMERIZATION OF OLEFIN, CATALYST FOR USE IN POLYMERIZATION OF OLEFIN, AND METHOD FOR PRODUCING OLEFIN POLYMER | 东邦钛株式会社 | 2016-08-10 | — | — | CN | disclosed |
| CN-103764689-B | The manufacture method of solid catalyst component for olefin polymerization, polymerization of olefines catalyzer and olefin polymer | TOHO TITANIUM CO.,LTD. (JP) | 2016-03-30 | — | — | CN | disclosed |
| CN-105008407-A | Process for producing propylene block copolymer | TOHO TITANIUM CO LTD | 2015-10-28 | — | — | CN | disclosed |
| CN-104822712-A | Solid catalyst component for polymerizing olefin, catalyst for polymerizing olefin, and method for producing polymerized olefin | TOHO TITANIUM CO LTD | 2015-08-05 | — | — | CN | disclosed |
| CN-104470953-A | Process for producing solid catalyst component for olefin polymerization, catalyst for olefin polymerization, and process for producing olefin polymer | TOHO TITANIUM CO LTD | 2015-03-25 | — | — | CN | disclosed |