Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | GAA | P10253 | 4/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 11/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 9/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | APP | P05067 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9994865 | 0.83 | MAPT (0.59) | MAPTGAATDP1ALDH1A1KDM4E | |
| SCHEMBL2931765 | 0.80 | MAPT (0.74) | MAPTGAATDP1ALDH1A1KDM4E | |
| SCHEMBL5492276 | 0.80 | MAPT (0.65) | MAPTGAATDP1ALDH1A1KDM4E | |
| SCHEMBL9183066 | 0.79 | MAPT (0.69) | MAPTGAATDP1ALDH1A1KDM4E | |
| SCHEMBL2944533 | 0.79 | MAPT (0.69) | MAPTGAATDP1ALDH1A1KDM4E | |
| SCHEMBL16532020 | 0.75 | MAPT (0.49) | MAPTGAATDP1ALDH1A1KDM4E | |
| SCHEMBL4607773 | 0.74 | MAPT (0.86) | MAPTGAATDP1ALDH1A1KDM4E | |
| SCHEMBL6563685 | 0.74 | MAPK13 (0.54) | MAPTGAATDP1ALDH1A1KDM4E | |
| SCHEMBL2602405 | 0.73 | MAPT (1.00) | MAPTGAATDP1ALDH1A1KDM4E | |
| SCHEMBL2764151 | 0.73 | MAPT (0.70) | MAPTGAATDP1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104418866-A | DGAT1 inhibitor, and preparation method and application thereof | NANJING MINGDE NEW DRUG RES AND DEV CO LTD | 2015-03-18 | — | — | CN | disclosed |