Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.65 |
| ▸ | GAA | P10253 | 6/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.61 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.61 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.61 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | APP | P05067 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
| ▸ | SNCA | P37840 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1921406 | 0.86 | MAPT (0.46) | MAPTGAATDP1MAPK14MAPK13 | |
| SCHEMBL9994865 | 0.84 | MAPT (0.59) | MAPTGAATDP1MAPK14MAPK13 | |
| SCHEMBL22814361 | 0.82 | MAPK13 (0.50) | MAPTTDP1MAPK14MAPK13MAPK12 | |
| SCHEMBL28005209 | 0.80 | MAPT (0.58) | MAPTGAATDP1MAPK14MAPK13 | |
| SCHEMBL4607773 | 0.80 | MAPT (0.86) | MAPTGAATDP1MAPK14MAPK13 | |
| SCHEMBL2602405 | 0.79 | MAPT (1.00) | MAPTGAATDP1MAPK14MAPK13 | |
| SCHEMBL7166997 | 0.78 | MAPT (0.75) | MAPTGAATDP1MAPK14MAPK13 | |
| SCHEMBL6360440 | 0.78 | KMT2A (0.48) | MAPTGAAMAPK14MAPK13MAPK12 | |
| SCHEMBL4945848 | 0.78 | MAPT (0.65) | MAPTGAATDP1MAPK14MAPK13 | |
| SCHEMBL6355590 | 0.78 | MAPK14 (0.47) | MAPTGAAMAPK14MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819341-A2 | IL-12 MODULATORY COMPOUNDS | Synta Pharmaceuticals Corporation (US) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006053227-A2 | IL-12 MODULATORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2006-05-18 | — | — | WO | disclosed |