Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.43 |
| ▸ | GUSB | P08236 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2803722 | 0.87 | HTR2C (0.43) | KMT2AMEN1NOD2HTR2CDRD2 | |
| SCHEMBL605086 | 0.83 | ADRB1 (0.49) | KMT2AMEN1NOD2HTR2CNPC1 | |
| Hydrochloric Acid SCHEMBL4131516 | 0.82 | ADRB1 (0.48) | KMT2AMEN1NOD2HTR2CNPC1 | |
| SCHEMBL605467 | 0.79 | DRD2 (0.64) | KMT2AMEN1HTR2CDRD2TSHR | |
| SCHEMBL604631 | 0.78 | ADRB1 (0.50) | KMT2AMEN1NOD2HTR2CNPC1 | |
| Hydrochloric Acid SCHEMBL4131473 | 0.77 | ADRB1 (0.49) | KMT2AMEN1NOD2HTR2CNPC1 | |
| SCHEMBL2803724 | 0.77 | KDM4E (0.45) | KMT2AHTR2CDRD2TSHRNPSR1 | |
| SCHEMBL604727 | 0.71 | ADRB1 (0.46) | HTR2CADRB1GUSB | |
| Hydrochloric Acid SCHEMBL4130738 | 0.71 | ADRB1 (0.45) | HTR2CADRB1GUSB | |
| SCHEMBL603888 | 0.69 | ADRB1 (0.44) | HTR2CADRB1GUSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200595-A2 | THIENO-AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | Janssen Pharmaceutica, N.V. (BE) | 2010-06-30 | — | — | EP | claimed |
| WO-2009038673-A2 | THIENO-AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-26 | — | — | WO | claimed |