Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2800566 | 0.87 | KMT2A (0.48) | HTR2CDRD2KMT2ATSHRNPSR1 | |
| SCHEMBL604727 | 0.83 | ADRB1 (0.46) | HTR2CADRB1PRKCI | |
| Hydrochloric Acid SCHEMBL4130738 | 0.82 | ADRB1 (0.45) | HTR2CADRB1PRKCI | |
| SCHEMBL604186 | 0.78 | ADRB1 (0.47) | HTR2CADRB1 | |
| Hydrochloric Acid SCHEMBL4126473 | 0.78 | ADRB1 (0.46) | HTR2CADRB1 | |
| SCHEMBL605467 | 0.77 | DRD2 (0.64) | HTR2CDRD2KMT2ATSHRNPSR1 | |
| SCHEMBL2803724 | 0.74 | KDM4E (0.45) | HTR2CDRD2KMT2ATSHRNPSR1 | |
| SCHEMBL605086 | 0.70 | ADRB1 (0.49) | HTR2CKMT2AADRB1NPC1MAPT | |
| Hydrochloric Acid SCHEMBL4131516 | 0.69 | ADRB1 (0.48) | HTR2CKMT2AADRB1NPC1MAPT | |
| SCHEMBL605525 | 0.67 | HRH4 (0.47) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200595-A2 | THIENO-AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | Janssen Pharmaceutica, N.V. (BE) | 2010-06-30 | — | — | EP | claimed |
| WO-2009038673-A2 | THIENO-AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-26 | — | — | WO | claimed |