SCHEMBL28009451

SCHEMBL28009451

c1ccc(Cc2ccccc2C(Cc2ccccc2)(Cc2ccccc2)Cc2ccccc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CALM1 P0DP23 1/20 0.44
HTR2A P28223 1/20 0.44
BCL2 P10415 1/20 0.42
BCL2L1 Q07817 1/20 0.42
LMNA P02545 1/20 0.41
CYP2D6 P10635 1/20 0.41
SLC6A2 P23975 1/20 0.39
TAAR1 Q96RJ0 1/20 0.39
CYP1A2 P05177 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
ALOX5 P09917 1/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
HPGD P15428 2/20 0.37
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
HIF1A Q16665 2/20 0.35
KEAP1 Q14145 1/20 0.35
CYP3A4 P08684 1/20 0.35
ALOX15 P16050 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11247243 0.82 HTR2A (0.42) CALM1HTR2ABCL2BCL2L1LMNA
SCHEMBL10601601 0.80 LMNA (0.47) CALM1HTR2ABCL2BCL2L1LMNA
Hydrochloric Acid SCHEMBL27762406 0.79 HTR2A (0.40) CALM1HTR2ABCL2BCL2L1LMNA
SCHEMBL3404551 0.79 CYP1A2 (0.42) CALM1HTR2ABCL2BCL2L1LMNA
SCHEMBL10360528 0.79 CYP1A2 (0.42) CALM1HTR2ABCL2BCL2L1LMNA
SCHEMBL5764360 0.78 CALM1 (0.48) CALM1HTR2ABCL2BCL2L1ALOX5
SCHEMBL5380250 0.77 KDM4E (0.56) CALM1HTR2ABCL2BCL2L1
SCHEMBL6546758 0.77 CALM1 (0.46) CALM1HTR2ABCL2BCL2L1LMNA
SCHEMBL12869583 0.75 CALM1 (0.44) CALM1HTR2ABCL2BCL2L1ALOX5
SCHEMBL10782398 0.75 CALM1 (0.44) CALM1HTR2ABCL2BCL2L1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104513126-B The preparation method and application of the many benzyl toluene of a kind of alkyl or alkyl dibenzyl toluene ZHAO CHAOHUA (CN) 2016-02-03 CN claimed
CN-104513126-A Preparation method and applications of alkyl multi-benzyl toluene or alkyl dibenzyl toluene ZHAO CHAOHUA 2015-04-15 CN claimed
CN-104513126-B The preparation method and application of the many benzyl toluene of a kind of alkyl or alkyl dibenzyl toluene ZHAO CHAOHUA (CN) 2016-02-03 CN disclosed
CN-104513126-A Preparation method and applications of alkyl multi-benzyl toluene or alkyl dibenzyl toluene ZHAO CHAOHUA 2015-04-15 CN disclosed