Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 6/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2093026 | 0.84 | ALOX5 (0.53) | ALOX5MAOBCYP4F2CYP4A11BCHE | |
| SCHEMBL3948493 | 0.80 | MAOB (0.58) | ALOX5MAOBCYP4F2CYP4A11BCHE | |
| SCHEMBL2772599 | 0.79 | MAOB (0.49) | ALOX5MAOBCYP4F2CYP4A11BCHE | |
| SCHEMBL622940 | 0.77 | GPR3 (0.41) | LMNACYP1A2SLC6A2SLC6A3 | |
| SCHEMBL6201987 | 0.77 | MAOB (0.50) | ALOX5MAOBCYP4F2CYP4A11BCHE | |
| SCHEMBL28422875 | 0.76 | MAOB (0.62) | ALOX5MAOBMRGPRX4PDK2CYP4F2 | |
| SCHEMBL920621 | 0.76 | ALOX5 (0.51) | ALOX5MAOBCYP4F2CYP4A11BCHE | |
| SCHEMBL27581024 | 0.75 | BCHE (0.47) | ALOX5MAOBCYP4F2CYP4A11BCHE | |
| SCHEMBL21268345 | 0.75 | CBFB (0.39) | MAOAABL1L3MBTL1CYP1A2CYP2C19 | |
| SCHEMBL5784957 | 0.74 | MRGPRX4 (0.63) | ALOX5MAOBMRGPRX4BCHEMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104583196-B | The method that 1,4-dibasic pyridazine analog and treatment lack relevant disease to SMN | 诺华股份有限公司 | 2016-10-12 | — | — | CN | disclosed |
| CN-104583196-A | 1,4-disubstituted pyridazine analogs and methods for treating SMN-deficiency-related conditions | NOVARTIS AG | 2015-04-29 | — | — | CN | disclosed |