Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | GRM8 | O00222 | 1/20 | 0.52 |
| ▸ | GRM6 | O15303 | 1/20 | 0.52 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.52 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.52 |
| ▸ | GSR | P00390 | 1/20 | 0.52 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.52 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.52 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.52 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.52 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.52 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.52 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.52 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.52 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.52 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29059542 | 1.00 | CYP1A2 (0.52) | CYP1A2GRM8GRM6GRIN2DGRIN3B | |
| SCHEMBL496858 | 0.90 | GRM8 (0.62) | CYP1A2GRM8GRM6GRIN2DGRIN3B | |
| SCHEMBL4959221 | 0.90 | GRM8 (0.62) | CYP1A2GRM8GRM6GRIN2DGRIN3B | |
| Hydrochloric Acid SCHEMBL10636419 | 0.88 | GRM8 (0.60) | CYP1A2GRM8GRM6GRIN2DGRIN3B | |
| SCHEMBL3402553 | 0.85 | GABRP (0.52) | CYP1A2GRM8GRM6GRIN2DGRIN3B | |
| SCHEMBL23777420 | 0.83 | SLC1A3 (0.39) | GRIK1SLC1A3SLC1A2SLC1A1GRIA4 | |
| SCHEMBL3411544 | 0.82 | BLM (0.57) | CYP1A2GRM8GRM6GRIN2DGRIN3B | |
| SCHEMBL1674762 | 0.82 | SLC1A1 (0.54) | CYP1A2GRM8GRM6GRIN2DGRIN3B | |
| SCHEMBL8838342 | 0.82 | CYP1A2 (0.54) | CYP1A2GRM8GRM6GRIN2DGRIN3B | |
| SCHEMBL23200441 | 0.82 | CYP1A2 (0.54) | CYP1A2GRM8GRM6GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2224804-A1 | TREATMENT OF CANCER WITH COMBINATIONS OF TOPOISOMERASE INHIBITORS AND PARP INHIBITORS | BiPar Sciences, Inc. (US) | 2010-09-08 | — | — | EP | disclosed |
| WO-2009073869-A1 | TREATMENT OF CANCER WITH COMBINATIONS OF TOPOISOMERASE INHIBITORS AND PARP INHIBITORS | BIPAR SCIENCES, INC. (US) | 2009-06-11 | — | — | WO | disclosed |
| EP-2059498-A2 | TREATMENT OF CANCER | Bipar Sciences, Inc. (US) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008030883-A2 | TREATMENT OF CANCER | BIPAR SCIENCES, INC. (US) | 2008-03-13 | — | — | WO | disclosed |