Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 12/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 12/20 | 0.45 |
| ▸ | HSD17B2 | P37059 | 4/20 | 0.45 |
| ▸ | HSD17B1 | P14061 | 3/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4288276 | 0.84 | PARP1 (0.44) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 | |
| SCHEMBL27877846 | 0.84 | MTNR1A (0.44) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 | |
| SCHEMBL1779795 | 0.84 | MTNR1A (0.44) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 | |
| SCHEMBL1007582 | 0.84 | MTNR1A (0.44) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 | |
| SCHEMBL2556980 | 0.81 | ALOX15 (0.45) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 | |
| SCHEMBL1548437 | 0.79 | MTNR1B (0.55) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 | |
| SCHEMBL7363893 | 0.79 | KDM4E (0.45) | — | |
| SCHEMBL15155861 | 0.75 | MAPT (0.48) | CES2CES1 | |
| SCHEMBL24402999 | 0.75 | HSD17B2 (0.51) | MTNR1AMTNR1BHSD17B2HSD17B1CES2 | |
| SCHEMBL28859256 | 0.75 | MTNR1A (0.41) | MTNR1AMTNR1BHSD17B2HSD17B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102153562-B | Spiro-oxindole compounds and their uses as therapeutic agents | XENON PHARMACEUTICALS INC | 2015-05-13 | — | — | CN | disclosed |