Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8736767 | 0.82 | MEN1 (0.43) | BRD4MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL504005 | 0.82 | L3MBTL1 (0.55) | BRD4MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL7200107 | 0.81 | RAB9A (0.57) | KDM4EBRD4MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27536175 | 0.79 | MEN1 (0.41) | BRD4MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL8782785 | 0.79 | MEN1 (0.41) | BRD4MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL2354804 | 0.79 | L3MBTL1 (0.43) | BRD4MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL28012007 | 0.79 | MTNR1A (0.45) | — | |
| SCHEMBL3780747 | 0.78 | MEN1 (0.40) | BRD4MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL14907285 | 0.78 | MEN1 (0.40) | BRD4MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL6182625 | 0.78 | CRHBP (0.41) | BRD4MEN1KMT2ACYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117303991-A | 4-trifluoromethyl substituted aromatic amine and synthesis method thereof | 江苏笃行致远新材料科技有限公司 | 2023-12-29 | — | — | CN | disclosed |
| CN-113416139-B | 4-fluorine substituted aryl amine compound and synthetic method thereof | 江苏笃行致远新材料科技有限公司 | 2022-06-03 | — | — | CN | disclosed |
| CN-113416139-A | 4-fluorine substituted aryl amine compound and synthetic method thereof | 江苏笃行致远新材料科技有限公司 | 2021-09-21 | — | — | CN | disclosed |
| CN-102746239-B | Uracil or thymine derivatives for the treatment of hepatitis C | ABBVIE INC. (BS) | 2016-02-10 | — | — | CN | disclosed |
| CN-101801935-B | Uracil or thymine derivatives for the treatment of hepatitis C | ABBOTT LAB | 2014-12-03 | — | — | CN | disclosed |
| CN-102746239-A | Uracil or thymine derivatives for the treatment of hepatitis C | ABBOTT LAB | 2012-10-24 | — | — | CN | disclosed |
| CN-101801935-A | Uracil or thymine derivatives for the treatment of hepatitis C | ABBOTT LAB | 2010-08-11 | — | — | CN | disclosed |
| EP-0595995-B1 | ARYLAMIDOALKYL- AND ARYLAMINOALKYL-N-HYDROXYUREA COMPOUNDS AND -N-HYDROXYFORMAMIDE DERIVATIVES HAVING LIPOXYGENASE INHIBITORY ACTIVITY | ABBOTT LAB (US) | 1997-01-15 | — | — | EP | disclosed |
| US-5514702-A | Arylamidoalkyl-N-hydroxyurea compounds having lipoxygenase inhibitory activity | ABBOTT LABORATORIES (US) | 1996-05-07 | — | — | US | disclosed |
| US-5214204-A | Inhibitors of biosynthesis of leukotrienes | ABBOTT LABORATORIES (US) | 1993-05-25 | — | — | US | disclosed |
| US-4657906-A | CARDIOVASCULAR DISORDERS | SMITH KLINE & FRENCH LABORATORIES LTD. (GB) | 1987-04-14 | — | — | US | disclosed |
| US-4556711-A | CARDIOTONIC AGENTS | SMITH KLINE & FRENCH LABORATORIES LTD. (US) | 1985-12-03 | — | — | US | disclosed |
| EP-0096517-A2 | Aryl pyrazinones | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1983-12-21 | — | — | EP | disclosed |