Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 7/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 7/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20160335 | 0.74 | PARP15 (0.44) | PARP15PARP10MTNR1APARP2SCN9A | |
| SCHEMBL27990764 | 0.72 | TLR4 (0.46) | PARP15PARP10MTNR1A | |
| SCHEMBL8651126 | 0.72 | PARP10 (0.48) | PARP15PARP10MTNR1APARP2BRD4 | |
| SCHEMBL22389473 | 0.72 | PARP10 (0.49) | PARP15PARP10MTNR1APARP2SCN9A | |
| SCHEMBL3428815 | 0.69 | PARP10 (0.49) | PARP15PARP10MTNR1APARP2SCN9A | |
| SCHEMBL29024848 | 0.67 | PARP15 (0.64) | PARP15PARP10PARP2 | |
| SCHEMBL25296446 | 0.67 | TLR4 (0.49) | PARP15PARP10 | |
| SCHEMBL27689472 | 0.67 | PARP15 (0.56) | PARP15PARP10PARP2 | |
| SCHEMBL13589518 | 0.66 | PTGS2 (0.53) | PARP15PARP10PARP2BRD4 | |
| SCHEMBL22389468 | 0.66 | RIPK1 (0.52) | PARP15PARP10SCN9ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104884451-A | Pyridinone and pyridazinone derivatives | ABBVIE INC | 2015-09-02 | — | — | CN | claimed |
| CN-104718201-A | Pyridinone and pyridazinone derivatives | ABBVIE INC | 2015-06-17 | — | — | CN | claimed |
| CN-104884451-A | Pyridinone and pyridazinone derivatives | ABBVIE INC | 2015-09-02 | — | — | CN | disclosed |
| CN-104718201-A | Pyridinone and pyridazinone derivatives | ABBVIE INC | 2015-06-17 | — | — | CN | disclosed |