Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 3/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL236487 | 0.98 | ESR1 (0.47) | ESR1ESR2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2286083 | 0.92 | SLC6A2 (0.53) | ESR1ESR2SLC6A2SLC6A4SLC6A3 | |
| Bicarbonate SCHEMBL28016114 | 0.88 | ACMSD (0.45) | ESR1ESR2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL236486 | 0.88 | ESR1 (0.49) | ESR1ESR2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL22573117 | 0.87 | HDAC4 (0.43) | ESR1ESR2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL236489 | 0.86 | ACMSD (0.46) | ESR1ESR2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL236823 | 0.84 | FABP3 (0.53) | FFAR4KDM4ELMNATDP1FABP7 | |
| SCHEMBL2286078 | 0.81 | SLC6A3 (0.54) | ESR1ESR2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL25274668 | 0.80 | ESR1 (0.55) | ESR1ESR2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7024866 | 0.80 | FFAR4 (0.47) | FFAR4LMNATDP1FABP7FABP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105714282-A | Method and apparatus for producing polycarbonate | 拜尔材料科学股份公司 | 2016-06-29 | — | — | CN | disclosed |
| CN-102102204-B | Method and apparatus for producing polycarbonate | BAYER MATERIALSCIENCE AG (DE) | 2016-04-27 | — | — | CN | disclosed |
| CN-105189445-A | Purification method of diphenyl carbonate for preparing high quality polycarbonate | SABIC INNOVATIVE PLASTICS IP | 2015-12-23 | — | — | CN | disclosed |
| CN-104640837-A | Process for the continuous manufacture of aryl alkyl carbonate and/or diaryl carbonate using vapor recompression | SABIC INNOVATIVE PLASTICS IP | 2015-05-20 | — | — | CN | disclosed |