Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.34 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30109166 | 0.76 | MEN1 (0.41) | ADRA2AADRA2BADRA2CALDH1A1CYP2A6 | |
| SCHEMBL436336 | 0.76 | MEN1 (0.41) | ADRA2AADRA2BADRA2CALDH1A1CYP2A6 | |
| SCHEMBL24701710 | 0.74 | ADRA2A (0.39) | ADRA2AADRA2BADRA2CALDH1A1CYP2A6 | |
| SCHEMBL15241791 | 0.74 | ADRA2A (0.39) | ADRA2AADRA2BADRA2CALDH1A1CYP2A6 | |
| SCHEMBL13180801 | 0.71 | SLC6A2 (0.43) | ADRA2AADRA2BADRA2CALDH1A1CYP2A6 | |
| SCHEMBL31122158 | 0.71 | ADRA2A (0.37) | ADRA2AADRA2BADRA2CALDH1A1CYP2A6 | |
| SCHEMBL11081014 | 0.71 | ADRA2A (0.50) | ADRA2AADRA2BADRA2CALDH1A1CYP2A6 | |
| SCHEMBL28910299 | 0.69 | ADRA2A (0.36) | ADRA2AADRA2BADRA2CALDH1A1CYP2A6 | |
| SCHEMBL5662790 | 0.69 | NOTUM (0.41) | ADRA2AADRA2BADRA2CALDH1A1CYP2A6 | |
| SCHEMBL28798997 | 0.69 | NOTUM (0.39) | ADRA2AADRA2BADRA2CALDH1A1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104854087-A | As P2X7Indole carboxamide derivatives of receptor antagonists | ACTELION PHARMACEUTICALS LTD | 2015-08-19 | — | — | CN | claimed |
| CN-104812749-A | Iindole carboxamide derivatives as p2x7 receptor antagonists | ACTELION PHARMACEUTICALS LTD | 2015-07-29 | — | — | CN | claimed |
| CN-104603127-A | Complement pathway modulators and uses thereof | NOVARTIS AG | 2015-05-06 | — | — | CN | claimed |
| CN-109069482-A | Substituted indole compound derivatives as inhibitors of dengue virus replication | 杨森制药公司 | 2018-12-21 | — | — | CN | disclosed |
| CN-108368044-A | Monosubstituted or disubstituted indole derivatives as inhibitors of dengue virus replication | 杨森制药公司 | 2018-08-03 | — | — | CN | disclosed |
| CN-107428685-A | Indole derivatives as inhibitors of dengue virus replication | 杨森制药公司 | 2017-12-01 | — | — | CN | disclosed |
| CN-107001265-A | Monosubstituted or disubstituted indoles as inhibitors of dengue virus replication | 杨森制药公司 | 2017-08-01 | — | — | CN | disclosed |
| CN-104854087-A | As P2X7Indole carboxamide derivatives of receptor antagonists | ACTELION PHARMACEUTICALS LTD | 2015-08-19 | — | — | CN | disclosed |
| CN-104812749-A | Iindole carboxamide derivatives as p2x7 receptor antagonists | ACTELION PHARMACEUTICALS LTD | 2015-07-29 | — | — | CN | disclosed |
| CN-104603127-A | Complement pathway modulators and uses thereof | NOVARTIS AG | 2015-05-06 | — | — | CN | disclosed |