Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.32 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4630556 | 0.79 | SLC6A2 (0.36) | ADRA2AADRA2BADRA2CALDH1A1CYP1A2 | |
| SCHEMBL22955613 | 0.78 | SLC6A2 (0.33) | SLC6A2SLC6A4 | |
| SCHEMBL4953965 | 0.78 | ALDH1A1 (0.36) | ALDH1A1CYP1A2MEN1KMT2ACA1 | |
| SCHEMBL4948527 | 0.78 | ALDH1A1 (0.34) | ADRA2BALDH1A1 | |
| SCHEMBL22955712 | 0.78 | ADRA2A (0.36) | ADRA2AADRA2BADRA2CCYP2A6CYP1A2 | |
| SCHEMBL436336 | 0.72 | MEN1 (0.41) | ADRA2AADRA2BADRA2CCYP2A6ALDH1A1 | |
| SCHEMBL30109166 | 0.72 | MEN1 (0.41) | ADRA2AADRA2BADRA2CCYP2A6ALDH1A1 | |
| SCHEMBL24701710 | 0.71 | ADRA2A (0.39) | ADRA2AADRA2BADRA2CCYP2A6ALDH1A1 | |
| SCHEMBL15241791 | 0.71 | ADRA2A (0.39) | ADRA2AADRA2BADRA2CCYP2A6ALDH1A1 | |
| SCHEMBL12543028 | 0.71 | P2RX7 (0.47) | ADRA2AADRA2BADRA2CP2RX7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12617774-B2 | Substituted indole compounds and methods of use thereof | NOVARTIS AG (CH) | 2026-05-05 | — | — | US | disclosed |
| US-20250289804-A1 | SUBSTITUTED INDOLE COMPOUNDS AND METHODS OF USE THEREOF | NOVARTIS PHARMA AG (CH) | 2025-09-18 | — | — | US | disclosed |
| US-20250243186-A1 | PIPERIDINYL INDOLE DERIVATIVES, PREPARATION METHODS AND MEDICINAL USES THEREOF | HANSOH BIO LLC. | 2025-07-31 | — | — | US | disclosed |
| US-20240287034-A1 | SUBSTITUTED INDOLE COMPOUNDS AND METHODS OF USE THEREOF | NOVARTIS PHARMA AG (CH) | 2024-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240287034-A1 | SUBSTITUTED INDOLE COMPOUNDS AND METHODS OF USE THEREOF | CFB, MAOB, CFH | ADRA2A 1213/4885ADRA2B 177/4885ADRA2C 696/4885 |
| US-20250289804-A1 | SUBSTITUTED INDOLE COMPOUNDS AND METHODS OF USE THEREOF | CFB, MAOB, CFH | ADRA2A 1213/4885ADRA2B 177/4885ADRA2C 696/4885 |
| US-12617774-B2 | Substituted indole compounds and methods of use thereof | CFB, CFD, TFPI | ADRA2A 673/4885ADRA2B 68/4885ADRA2C 364/4885 |
| US-20250243186-A1 | PIPERIDINYL INDOLE DERIVATIVES, PREPARATION METHODS AND MEDICINAL USES THEREOF | IDO1, IDO2, TPH1 | ADRA2A 219/4885ADRA2B 315/4885ADRA2C 124/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.