Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.79 |
| ▸ | NPC1 | O15118 | 3/20 | 0.79 |
| ▸ | RAB9A | P51151 | 3/20 | 0.79 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | FBP1 | P09467 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.45 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL62411 | 0.88 | MAPT (1.00) | MAPTNPC1RAB9APOLBL3MBTL1 | |
| SCHEMBL62412 | 0.88 | MAPT (1.00) | MAPTNPC1RAB9APOLBL3MBTL1 | |
| SCHEMBL439935 | 0.87 | APP (0.64) | MAPTNPC1RAB9AAPPFBP1 | |
| Pyrazine SCHEMBL27515795 | 0.80 | MAPT (0.65) | MAPTNPC1RAB9APOLBL3MBTL1 | |
| SCHEMBL545380 | 0.80 | — | — | |
| SCHEMBL5248686 | 0.79 | ALDH1A1 (0.62) | MAPTNPC1RAB9APOLBL3MBTL1 | |
| Ammonia Solution, Strong SCHEMBL27496972 | 0.78 | MAPT (0.63) | MAPTNPC1RAB9APOLBL3MBTL1 | |
| Hydrochloric Acid SCHEMBL27929116 | 0.78 | MAPT (0.63) | MAPTNPC1RAB9APOLBL3MBTL1 | |
| SCHEMBL14880657 | 0.78 | HSPB1 (0.60) | MAPTNPC1RAB9APOLBAPP | |
| SCHEMBL14880514 | 0.78 | MAOB (0.58) | MAPTNPC1RAB9AAPPFBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104603133-A | Combination therapy for the treatment of cancer and immunosuppression | BASILEA PHARMACEUTICA AG | 2015-05-06 | — | — | CN | disclosed |