Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 8/20 | 0.64 |
| ▸ | KDR | P35968 | 5/20 | 0.64 |
| ▸ | JAK3 | P52333 | 4/20 | 0.64 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.64 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 3/20 | 0.43 |
| ▸ | SRC | P12931 | 3/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | TEK | Q02763 | 3/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15638437 | 0.89 | LCK (0.60) | LCKKDRJAK3MAPK14ADORA1 | |
| SCHEMBL28019341 | 0.86 | LCK (0.78) | LCKKDRJAK3MAPK14ADORA1 | |
| SCHEMBL15637197 | 0.84 | LCK (0.60) | LCKKDRJAK3MAPK14TGFBR1 | |
| SCHEMBL5496119 | 0.81 | LCK (0.66) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL28018836 | 0.81 | PIK3CD (0.48) | LCKKDRJAK3MAPK14TGFBR1 | |
| SCHEMBL28019351 | 0.79 | DHFR (0.58) | TGFBR1ADORA2AHSP90AB1 | |
| SCHEMBL5494575 | 0.78 | LCK (1.00) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL28019362 | 0.76 | TGFBR1 (0.64) | TGFBR1FEN1 | |
| SCHEMBL5504290 | 0.76 | LCK (0.70) | LCKKDRJAK3MAPK14ADORA1 | |
| SCHEMBL28047020 | 0.75 | PTGS2 (0.56) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104837832-A | GDF-8 inhibitors | RIGEL PHARMACEUTICALS INC | 2015-08-12 | — | — | CN | claimed |
| CN-104837832-A | GDF-8 inhibitors | RIGEL PHARMACEUTICALS INC | 2015-08-12 | — | — | CN | disclosed |