Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 15/20 | 0.70 |
| ▸ | KDR | P35968 | 8/20 | 0.70 |
| ▸ | JAK3 | P52333 | 5/20 | 0.70 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.70 |
| ▸ | KIT | P10721 | 8/20 | 0.46 |
| ▸ | SRC | P12931 | 8/20 | 0.46 |
| ▸ | TEK | Q02763 | 3/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24457867 | 0.84 | LCK (0.50) | LCKKDRJAK3MAPK14TEK | |
| SCHEMBL5494575 | 0.82 | LCK (1.00) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL42089 | 0.79 | LCK (0.73) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL17803857 | 0.78 | LCK (0.62) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL28298101 | 0.77 | LCK (0.69) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL28134708 | 0.76 | TGFBR1 (0.51) | LCKKDRJAK3MAPK14CTSD | |
| SCHEMBL28019339 | 0.76 | LCK (0.64) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL15638437 | 0.76 | LCK (0.60) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL5492816 | 0.75 | LCK (0.72) | LCKKDRJAK3MAPK14KIT | |
| SCHEMBL5489139 | 0.75 | LCK (0.72) | LCKKDRJAK3MAPK14KIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070054916-A1 | Aryl nitrogen-containing bicyclic compounds and methods of use | AMGEN INC. | 2007-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070054916-A1 | Aryl nitrogen-containing bicyclic compounds and methods of use | MAP3K1, MAP3K5, MAP3K2 | LCK 106/4885KDR 1044/4885JAK3 60/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.