Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | LOX | P28300 | 1/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13827585 | 0.83 | PDE10A (0.43) | HTR7LOXLOXL2MTNR1AMTNR1B | |
| SCHEMBL8496930 | 0.81 | LOX (0.39) | HTR7LOXLOXL2MTNR1AMTNR1B | |
| SCHEMBL29442793 | 0.81 | LOX (0.39) | HTR7LOXLOXL2MTNR1AMTNR1B | |
| SCHEMBL28128988 | 0.79 | TSHR (0.35) | HTR7TSHRPDE10ANOS2 | |
| SCHEMBL28019823 | 0.79 | HTR7 (0.58) | HTR7LOXLOXL2MTNR1AMTNR1B | |
| SCHEMBL83512 | 0.79 | PDE10A (0.44) | HTR7TAAR1PDE10AFGFR1FGFR2 | |
| SCHEMBL2632841 | 0.79 | TAAR1 (0.41) | LOXLOXL2MTNR1AMTNR1BTAAR1 | |
| SCHEMBL28020330 | 0.78 | TSHR (0.38) | LOXLOXL2MTNR1AMTNR1BTAAR1 | |
| SCHEMBL7712102 | 0.77 | MTNR1A (0.37) | HTR7LOXLOXL2MTNR1AMTNR1B | |
| SCHEMBL3511885 | 0.77 | LOXL2 (0.52) | HTR7LOXLOXL2MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104725397-A | Thienopyrimidine derivatives, a process for their preparation and pharmaceutical compositions containing them | SERVIER LAB | 2015-06-24 | — | — | CN | disclosed |