SCHEMBL28020501

SCHEMBL28020501

CC(C)COc1ccccc1C(=O)OOC(C)(C)C

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.47
TSHR P16473 2/20 0.47
HSD17B10 Q99714 1/20 0.47
TDP1 Q9NUW8 1/20 0.47
HTT P42858 1/20 0.43
ABCB1 P08183 2/20 0.42
ADRB2 P07550 2/20 0.40
ADRB1 P08588 2/20 0.40
ADRB3 P13945 2/20 0.40
KDM4E B2RXH2 2/20 0.38
SIRT2 Q8IXJ6 1/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
LMNA P02545 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
TP53 P04637 1/20 0.38
MAPT P10636 1/20 0.38
NPY1R P25929 1/20 0.38
NPY2R P49146 1/20 0.38
ATM Q13315 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28020534 0.81 IRAK4 (0.57) ALDH1A1TSHRHSD17B10TDP1KDM4E
SCHEMBL385218 0.80 ALDH1A1 (0.54) ALDH1A1TSHRHTTMEN1KMT2A
SCHEMBL28020498 0.80 ALDH1A1 (0.74) ALDH1A1TSHRTDP1HTTABCB1
SCHEMBL25063217 0.79 ALDH1A1 (0.53) ALDH1A1TSHRHTTABCB1ADRB2
SCHEMBL28020074 0.79 ALDH1A1 (0.53) ALDH1A1TSHRHTTABCB1ADRB2
SCHEMBL24074185 0.79 ALDH1A1 (0.53) ALDH1A1TSHRHTTABCB1ADRB2
SCHEMBL4337394 0.79 ALDH1A1 (0.53) ALDH1A1TSHRHTTABCB1ADRB2
SCHEMBL263306 0.79 HSD17B10 (0.56) ALDH1A1TSHRHSD17B10TDP1HTT
SCHEMBL7926507 0.78 ALDH1A1 (0.51) ALDH1A1TSHRHSD17B10HTTABCB1
SCHEMBL28020536 0.78 TSHR (0.61) ALDH1A1TSHRHSD17B10HTTABCB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104829756-A Solid catalyst component for olefin polymerization, and preparation method and application thereof CHINESE ACAD INST CHEMISTRY 2015-08-12 CN disclosed