Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10771231 | 0.79 | TSHR (0.57) | RAB9ASMN1; SMN2POLBTSHRKDM4E | |
| SCHEMBL30606641 | 0.78 | ELANE (0.43) | P2RX7KDM4EALDH1A1HSP90AA1 | |
| SCHEMBL15911401 | 0.78 | P2RX7 (0.51) | P2RX7KDM4EBRAFKDRMAPK14 | |
| SCHEMBL6648327 | 0.76 | P2RX7 (0.41) | HPGDSMN1; SMN2P2RX7KDM4EBRAF | |
| SCHEMBL3548849 | 0.76 | RAB9A (0.46) | RAB9AHPGDSMN1; SMN2POLBKDM4E | |
| SCHEMBL12470613 | 0.75 | HSP90AA1 (0.40) | RAB9AHPGDSMN1; SMN2POLBTSHR | |
| SCHEMBL5968188 | 0.75 | ELANE (0.44) | RAB9AP2RX7KDM4EBRAFKDR | |
| SCHEMBL27851405 | 0.74 | KDM4E (0.51) | RAB9AHPGDSMN1; SMN2KDM4EGAA | |
| SCHEMBL30575119 | 0.74 | HSP90AA1 (0.39) | RAB9AHPGDSMN1; SMN2POLBTSHR | |
| SCHEMBL29080505 | 0.74 | HSP90AA1 (0.39) | RAB9AHPGDSMN1; SMN2POLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110325516-A | HETEROARYL COMPOUNDS AND THEIR USE | 米尼奥尔克斯治疗有限公司 | 2019-10-11 | — | — | CN | disclosed |
| CN-108349963-A | sodium channel blockers | 株式会社大熊制药 | 2018-07-31 | — | — | CN | disclosed |
| CN-104854107-A | Pyrrolopyrimidine compounds as kinase inhibitors | PHARMACYCLICS INC | 2015-08-19 | — | — | CN | disclosed |