Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SLC18A3 | Q16572 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27933965 | 0.75 | ALDH1A1 (0.38) | SMN1; SMN2ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL3858877 | 0.73 | GAA (0.54) | GAAMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL6201226 | 0.73 | GAA (0.54) | GAAMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL6201220 | 0.73 | GAA (0.54) | GAAMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL3866711 | 0.73 | GAA (0.54) | GAAMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL28022342 | 0.72 | ALDH1A1 (0.38) | NPC1RAB9AALDH1A1 | |
| SCHEMBL1578062 | 0.70 | GAA (1.00) | GAAMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL16615455 | 0.70 | GAA (0.53) | GAAMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL6290035 | 0.67 | ALDH1A1 (0.60) | GAAMAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL6290034 | 0.67 | ALDH1A1 (0.60) | GAAMAPTSMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104703980-A | Orexin receptor antagonists which are [ortho bi (hetero )aryl]-[2-(meta bi (hetero )aryl)-pyrrolidin-1-yl]-methanone derivatives | ACTELION PHARMACEUTICALS LTD | 2015-06-10 | — | — | CN | disclosed |