Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.67 |
| ▸ | USP2 | O75604 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.66 |
| ▸ | PKM | P14618 | 5/20 | 0.66 |
| ▸ | HTT | P42858 | 4/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | NAMPT | P43490 | 1/20 | 0.59 |
| ▸ | HTR7 | P34969 | 2/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
| ▸ | HTR6 | P50406 | 1/20 | 0.58 |
| ▸ | PLAU | P00749 | 2/20 | 0.58 |
| ▸ | CA12 | O43570 | 2/20 | 0.57 |
| ▸ | CA1 | P00915 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28023890 | 0.90 | LMNA (0.81) | LMNAALOX15USP2ALDH1A1PKM | |
| SCHEMBL2703229 | 0.89 | LMNA (0.80) | LMNAALOX15USP2ALDH1A1PKM | |
| SCHEMBL28023297 | 0.87 | LMNA (0.66) | LMNAALOX15USP2ALDH1A1PKM | |
| SCHEMBL28023893 | 0.86 | NAMPT (0.61) | LMNAALOX15USP2ALDH1A1PKM | |
| SCHEMBL2704273 | 0.85 | PKM (0.78) | LMNAALOX15USP2ALDH1A1PKM | |
| SCHEMBL11875 | 0.82 | LMNA (0.80) | LMNAALOX15USP2ALDH1A1PKM | |
| SCHEMBL2702712 | 0.81 | PKM (0.74) | PKM | |
| SCHEMBL28023852 | 0.81 | ALDH1A1 (0.82) | LMNAALOX15USP2ALDH1A1PKM | |
| SCHEMBL17947677 | 0.80 | ALDH1A1 (1.00) | LMNAALOX15USP2ALDH1A1PKM | |
| SCHEMBL16206625 | 0.78 | LMNA (0.68) | LMNAALOX15USP2ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104817498-A | Therapeutic compounds and compositions | AGIOS PHARMACEUTICALS INC | 2015-08-05 | — | — | CN | disclosed |