Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.60 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.60 |
| ▸ | USP2 | O75604 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | PKLR | P30613 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | UBE2N | P61088 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2702415 | 0.88 | TSHR (0.63) | LMNAALOX15USP2PKMPKLR | |
| SCHEMBL28023293 | 0.86 | LMNA (0.67) | NAMPTLMNAALOX15USP2PKM | |
| SCHEMBL2702712 | 0.86 | PKM (0.74) | PKMPKLR | |
| SCHEMBL19040907 | 0.86 | ALDH1A1 (0.64) | LMNAUSP2PKMALDH1A1MAPK1 | |
| SCHEMBL28023890 | 0.85 | LMNA (0.81) | NAMPTLMNAALOX15USP2PKM | |
| SCHEMBL2702504 | 0.84 | PKM (0.77) | NAMPTLMNAPKMALDH1A1HTT | |
| SCHEMBL2703229 | 0.83 | LMNA (0.80) | NAMPTLMNAALOX15USP2PKM | |
| SCHEMBL28023297 | 0.82 | LMNA (0.66) | NAMPTLMNAALOX15USP2PKM | |
| SCHEMBL28023852 | 0.80 | ALDH1A1 (0.82) | NAMPTLMNAALOX15USP2PKM | |
| SCHEMBL12975161 | 0.79 | LMNA (0.68) | LMNAALOX15USP2PKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104817498-A | Therapeutic compounds and compositions | AGIOS PHARMACEUTICALS INC | 2015-08-05 | — | — | CN | disclosed |