Acetylcholine

Acetylcholine

SCHEMBL28024294

CC(=O)OCC[N+](C)(C)C.Cc1ccc(S(=O)(=O)O)cc1.N

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetylcholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 known ✓ P17787 2/20 0.56
CHRNA4 known ✓ P43681 2/20 0.56
CHRM1 P11229 6/20 0.56
CHRM3 P20309 6/20 0.56
CHRM2 P08172 5/20 0.56
CHRM4 P08173 5/20 0.56
CHRM5 P08912 4/20 0.56
HTR1A P08908 2/20 0.56
CHRNA7 P36544 2/20 0.56
SMN1; SMN2 Q16637 2/20 0.56
PGR P06401 1/20 0.56
TBXA2R P21731 1/20 0.56
CHRNB4 P30926 1/20 0.56
CHRNA3 P32297 1/20 0.56
CHRNA10 Q9GZZ6 1/20 0.56
CHRNA9 Q9UGM1 1/20 0.56
GALR3 O60755 2/20 0.54
GAA P10253 2/20 0.54
RAB9A P51151 1/20 0.54
CYP1A2 P05177 3/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetylcholine SCHEMBL14840381 0.98 CHRM1 (0.58) CHRM1CHRM3CHRM2CHRM4CHRM5
Acetylcholine SCHEMBL14840380 0.87 CHRM1 (0.58) CHRM1CHRM3CHRM2CHRM4CHRM5
Ammonia Solution, Strong SCHEMBL27752712 0.86 CYP1A2 (0.43) CHRM1CHRM3CHRM2CHRM4CHRM5
SCHEMBL28167924 0.85 CYP1A2 (0.49) CHRM1CHRM3CHRM2CHRM4CHRM5
SCHEMBL1262971 0.85 CYP1A2 (0.43) CHRM1CHRM3CHRM2CHRM4CHRM5
SCHEMBL1403432 0.82 CYP1A2 (0.43) CHRM1CHRM3CHRM2CHRM4CHRM5
Ethyl Acetate SCHEMBL3246104 0.81 ALDH1A1 (0.50) SMN1; SMN2GAARAB9ACYP1A2CYP2C9
Choline SCHEMBL27636047 0.78 ALDH1A1 (0.44) SMN1; SMN2GAACYP1A2CYP2C9MAPT
Acetylcholine SCHEMBL8513991 0.77 CHRM1 (0.95) CHRM1CHRM3CHRM2CHRM4CHRM5
SCHEMBL9187580 0.77 CHRNB4 (0.47) CHRNB2CHRNA7CHRNA4SMN1; SMN2CHRNB4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103890056-B Carbon fiber-reinforced thermoplastic resin composition, molding material, prepreg, and methods for producing same TORAY INDUSTRIES 2015-07-22 CN disclosed