Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 2/20 | 0.43 |
| ▸ | CDK8 | P49336 | 2/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 7/20 | 0.38 |
| ▸ | PNP | P00491 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28148153 | 0.83 | PDE10A (0.44) | CCNCCDK8GRM2 | |
| SCHEMBL28821086 | 0.82 | CCNC (0.41) | CCNCCDK8PIM1NAMPTGRM2 | |
| SCHEMBL28024317 | 0.78 | CCNC (0.48) | CCNCCDK8PIM1GRM2TSHR | |
| SCHEMBL15741758 | 0.76 | CCNC (0.46) | CCNCCDK8PIM1HRH4 | |
| SCHEMBL28024785 | 0.76 | CCNC (0.43) | CCNCCDK8PIM1GRM2TSHR | |
| SCHEMBL14266820 | 0.75 | LMNA (0.41) | CCNCCDK8 | |
| SCHEMBL28024769 | 0.74 | CCNC (0.44) | CCNCCDK8PIM1 | |
| SCHEMBL28821388 | 0.73 | CCNC (0.44) | CCNCCDK8PIM1 | |
| SCHEMBL1319809 | 0.71 | CCNC (0.49) | CCNCCDK8PIM1GRM2TSHR | |
| SCHEMBL15742996 | 0.69 | CCNC (0.62) | CCNCCDK8PIM1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104812387-A | Substituted 1, 6-naphthyridines | HOFFMANN LA ROCHE | 2015-07-29 | — | — | CN | disclosed |