Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 10/20 | 0.44 |
| ▸ | CDK8 | P49336 | 10/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | NNMT | P40261 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.32 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28024317 | 0.83 | CCNC (0.48) | CCNCCDK8PIM1 | |
| SCHEMBL28821388 | 0.80 | CCNC (0.44) | CCNCCDK8PIM1PDE10ACYP11B2 | |
| SCHEMBL15741758 | 0.78 | CCNC (0.46) | CCNCCDK8PIM1NNMT | |
| SCHEMBL28148153 | 0.77 | PDE10A (0.44) | CCNCCDK8PDE10ACYP11B1CYP11B2 | |
| SCHEMBL28024785 | 0.75 | CCNC (0.43) | CCNCCDK8PIM1 | |
| SCHEMBL4729623 | 0.74 | P2RX7 (0.44) | CCNCCDK8ALDH1A1 | |
| SCHEMBL28024329 | 0.74 | CCNC (0.43) | CCNCCDK8PIM1 | |
| SCHEMBL10138393 | 0.72 | CCNC (0.54) | CCNCCDK8APP | |
| SCHEMBL15743010 | 0.72 | CCNC (0.61) | CCNCCDK8PIM1CYP11B1CYP11B2 | |
| SCHEMBL1318925 | 0.71 | CCNC (0.39) | CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104812387-A | Substituted 1, 6-naphthyridines | HOFFMANN LA ROCHE | 2015-07-29 | — | — | CN | claimed |
| CN-104812387-A | Substituted 1, 6-naphthyridines | HOFFMANN LA ROCHE | 2015-07-29 | — | — | CN | disclosed |