Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 5/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28024329 | 0.83 | CCNC (0.43) | GRM2CCNCCDK8 | |
| SCHEMBL28821086 | 0.82 | CCNC (0.41) | GRM2CYP2C9CCNCCDK8 | |
| SCHEMBL15742774 | 0.79 | CCNC (0.65) | CYP11B1CYP11B2GRM2CCNCCDK8 | |
| SCHEMBL28024769 | 0.77 | CCNC (0.44) | PDE10ACYP11B1CYP11B2CCNCCDK8 | |
| SCHEMBL4578523 | 0.76 | PTGS1 (0.43) | CYP11B1CYP11B2CCNCCDK8MAP4K4 | |
| SCHEMBL28148152 | 0.75 | PDE10A (0.43) | PDE10ACYP11B1CYP11B2CYP19A1CYP2C9 | |
| SCHEMBL28024317 | 0.73 | CCNC (0.48) | GRM2CCNCCDK8 | |
| SCHEMBL29670400 | 0.73 | FTO (0.48) | CYP11B1CYP11B2CYP19A1CYP2C9MAP4K4 | |
| SCHEMBL28024785 | 0.71 | CCNC (0.43) | GRM2CCNCCDK8 | |
| SCHEMBL28821388 | 0.71 | CCNC (0.44) | PDE10ACYP11B2CCNCCDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106817900-A | Novel naphthyridines and isoquinolin and its purposes as CDK8/19 inhibitor | 默克专利有限公司 | 2017-06-09 | — | — | CN | disclosed |