Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetophenone SCHEMBL28410239 | 0.82 | LMNA (0.47) | KMT2AALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| 4-Hydroxyacetophenone SCHEMBL28289945 | 0.81 | HSD17B1 (0.55) | KMT2ANPSR1ALDH1A1HSD17B10SMN1; SMN2 | |
| Methyl 4-Pyridylketone SCHEMBL27868126 | 0.79 | NAPRT (0.50) | KMT2ANPSR1ALDH1A1HSD17B10HTT | |
| Methyl 4-Pyridylketone SCHEMBL55235 | 0.79 | — | — | |
| Methyl 4-Pyridylketone SCHEMBL27943810 | 0.77 | NAPRT (0.48) | KMT2ANPSR1ALDH1A1HSD17B10HTT | |
| Methyl 4-Pyridylketone SCHEMBL27911491 | 0.77 | NAPRT (0.56) | KMT2AALDH1A1HSD17B10HTTSMN1; SMN2 | |
| Pyrazine SCHEMBL27608305 | 0.77 | KMT2A (0.31) | KMT2ANPSR1 | |
| Methyl 4-Pyridylketone SCHEMBL28979293 | 0.77 | NAPRT (0.56) | KMT2AALDH1A1HSD17B10HTTSMN1; SMN2 | |
| Ethoxycarbonyl Group SCHEMBL27620342 | 0.77 | GCGR (0.36) | KMT2ANPSR1RECQLMAPTMEN1 | |
| Methyl 4-Pyridylketone SCHEMBL28826915 | 0.75 | NAPRT (0.54) | KMT2AALDH1A1HSD17B10HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109641854-A | Integration stress access regulator | 卡里科生命科学有限责任公司 | 2019-04-16 | — | — | CN | disclosed |
| CN-108467369-A | BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS | 诺华股份有限公司 | 2018-08-31 | — | — | CN | disclosed |
| CN-105143209-B | Biaryl amide compounds as kinase inhibitors | 诺华股份有限公司 | 2018-03-13 | — | — | CN | disclosed |
| CN-105143209-A | Biaryl amide compounds as kinase inhibitors | NOVARTIS AG | 2015-12-09 | — | — | CN | disclosed |