Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18583320 | 0.84 | RAB9A (0.48) | SMN1; SMN2MAPTNPC1HPGDMEN1 | |
| SCHEMBL6113275 | 0.83 | MEN1 (0.52) | SMN1; SMN2MAPTNPC1HPGDMEN1 | |
| SCHEMBL2126690 | 0.83 | MEN1 (0.52) | SMN1; SMN2MAPTNPC1HPGDMEN1 | |
| SCHEMBL31186730 | 0.83 | MEN1 (0.52) | SMN1; SMN2MAPTNPC1HPGDMEN1 | |
| SCHEMBL30364839 | 0.82 | CYP46A1 (0.56) | SMN1; SMN2MAPTNPC1HPGDMEN1 | |
| SCHEMBL1170022 | 0.82 | CYP46A1 (0.56) | SMN1; SMN2MAPTNPC1HPGDMEN1 | |
| SCHEMBL16502297 | 0.81 | MAPT (0.36) | SMN1; SMN2MAPTNPC1HPGDMEN1 | |
| SCHEMBL16127178 | 0.81 | KEAP1 (0.43) | SMN1; SMN2MAPTNPC1HPGDMEN1 | |
| SCHEMBL23243818 | 0.81 | LOXL2 (0.42) | SMN1; SMN2MAPTNPC1HPGDKMT2A | |
| SCHEMBL6893999 | 0.80 | MEN1 (0.49) | SMN1; SMN2MAPTNPC1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104854087-A | As P2X7Indole carboxamide derivatives of receptor antagonists | ACTELION PHARMACEUTICALS LTD | 2015-08-19 | — | — | CN | disclosed |
| CN-104812749-A | Iindole carboxamide derivatives as p2x7 receptor antagonists | ACTELION PHARMACEUTICALS LTD | 2015-07-29 | — | — | CN | disclosed |