SCHEMBL1170022

SCHEMBL1170022

COC(=O)c1cc(C)ccc1C

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP46A1 Q9Y6A2 1/20 0.56
NR4A2 P43354 2/20 0.53
TDP1 Q9NUW8 1/20 0.52
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
MAPT P10636 3/20 0.49
HPGD P15428 2/20 0.49
SMN1; SMN2 Q16637 2/20 0.49
NPC1 O15118 1/20 0.49
CA12 O43570 2/20 0.46
CA1 P00915 2/20 0.46
CA2 P00918 2/20 0.46
CA7 P43166 2/20 0.46
CA9 Q16790 2/20 0.46
CA14 Q9ULX7 2/20 0.46
CISD2 Q8N5K1 1/20 0.46
PDK2 Q15119 1/20 0.46
PDK4 Q16654 1/20 0.46
NPSR1 Q6W5P4 2/20 0.44
HSP90AA1 P07900 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30364839 1.00 CYP46A1 (0.56) CYP46A1NR4A2TDP1MEN1KMT2A
SCHEMBL1206018 0.85 CYP46A1 (0.57) CYP46A1NR4A2TDP1MAPTHPGD
SCHEMBL2126690 0.85 MEN1 (0.52) CYP46A1NR4A2MEN1KMT2AMAPT
SCHEMBL6113275 0.85 MEN1 (0.52) CYP46A1MEN1KMT2AMAPTHPGD
SCHEMBL31186730 0.85 MEN1 (0.52) CYP46A1MEN1KMT2AMAPTHPGD
SCHEMBL7666837 0.85 ALDH1A1 (0.50) CYP46A1NR4A2TDP1KMT2AMAPT
SCHEMBL70184 0.83 KDM4E (0.47) CYP46A1NR4A2TDP1MAPTHPGD
SCHEMBL158111 0.83 TDP1 (0.57) CYP46A1NR4A2TDP1MEN1KMT2A
SCHEMBL20484462 0.82 MEN1 (0.49) CYP46A1MEN1KMT2AMAPTHPGD
SCHEMBL6893999 0.82 MEN1 (0.49) CYP46A1MEN1KMT2AMAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 145 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118184679-A Photothermal agent and preparation method thereof, photothermal nanoparticle and preparation method thereof, insulating material and self-repairing method of insulating material 中国石油天然气股份有限公司 2024-06-14 CN claimed
US-20260028326-A1 COMPOUND BASED ON ISOINDOLINE-SUBSTITUTED GLUTARIMIDE BACKBONE AND USE THEREOF GLUETACS THERAPEUTICS SHANGHAI CO LTD (CN) 2026-01-29 US disclosed
EP-4185858-B1 COMPOSITIONS, SYSTEMS AND METHODS FOR BIOLOGICAL ANALYSIS USING DYES LIFE TECHNOLOGIES CORP (US) 2025-05-21 EP disclosed
US-20250114436-A1 DYNAMIC-COVALENT HYDROGELS WITH GLUCOSE-SPECIFIC AND GLUCOSE-RESPONSIVE DIBORONATE CROSSLINKING UNIVERSITY OF NOTRE DAME DU LAC 2025-04-10 US disclosed
EP-4452322-A2 DYNAMIC-COVALENT HYDROGELS WITH GLUCOSE-SPECIFIC AND GLUCOSE-RESPONSIVE DIBORONATE CROSSLINKING University of Notre Dame du Lac (US) 2024-10-30 EP disclosed
EP-4446324-A1 LIGAND COMPOUNDS FOR E3 UBIQUITIN LIGASE, PROTEIN DEGRADERS DEVELOPED ON BASIS OF LIGAND COMPOUNDS, AND USES THEREOF Gluetacs Therapeutics (Shanghai) Co., Ltd. (CN) 2024-10-16 EP disclosed
CN-118184679-A Photothermal agent and preparation method thereof, photothermal nanoparticle and preparation method thereof, insulating material and self-repairing method of insulating material 中国石油天然气股份有限公司 2024-06-14 CN disclosed
CN-117881668-A Compound based on isoindoline substituted glutarimide skeleton and application thereof 标新生物医药科技(上海)有限公司 2024-04-12 CN disclosed
US-20240060117-A1 ENERGY TRANSFER DYE CONJUGATES FOR USE IN BIOLOGICAL ASSAYS Life Technologies Corporation 2024-02-22 US disclosed
WO-2024032689-A1 COMPOUND BASED ON ISOINDOLINE-SUBSTITUTED GLUTARIMIDE BACKBONE AND USE THEREOF 标新生物医药科技(上海)有限公司 2024-02-15 WO disclosed
US-20030153570-A1 Aryl triazines as LPAAT-SS inhibitors and uses thereof CELL THERAPEUTICS, INC. (US) 2003-08-14 US disclosed
US-20030149016-A1 Novel carbapenem derivatives KANO YUKO (JP) 2003-08-07 US disclosed
WO-2003037346-A1 6-PHENYL-N-PHENYL-(1,3,5) -TRIAZINE-2,4-DIAMINE DERIVATIVES AND RELATED COMPOUNDS WITH LYSOPHPHOSPHATIDIC ACID ACYLTRANSFERASE BETA (LPAAT-BETA) INHIBITORY ACTIVITY FOR USE IN THE TREATMENT OF CANCER CELL THERAPEUTICS, INC. (US) 2003-05-08 WO disclosed
EP-1101766-A1 NOVEL CARBAPENEM DERIVATIVES MEIJI SEIKA KAISHA LTD. (JP) 2001-05-23 EP disclosed
US-RE36617-E Anastrozole and salts as anticancer agent ZENECA LIMITED (GB) 2000-03-14 US disclosed
EP-0507013-B1 Process for the preparation of aromatic beta-diketones WITCO CORP (US) 1996-02-07 EP disclosed
EP-0507013-A1 Process for the preparation of aromatic beta-diketones WITCO CORPORATION (US) 1992-10-07 EP disclosed
US-5015777-A Reaction of an acetophenone and an aliphatic ester or an ester of benzoic acid in the presence of sodium alkoxide condensation agent in an aromatic solvent WITCO CORPORATION (US) 1991-05-14 US disclosed
US-4935437-A (Substituted aralkyl) heterocyclic compounds IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1990-06-19 US disclosed
EP-0296749-A1 (Substituted aralkyl) heterocyclic compounds ZENECA LIMITED (GB) 1988-12-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260028326-A1 COMPOUND BASED ON ISOINDOLINE-SUBSTITUTED GLUTARIMIDE BACKBONE AND USE THEREOF CDR2, CYC1, CLN6 CYP46A1 3116/4885NR4A2 826/4885TDP1 1633/4885
US-20030153570-A1 Aryl triazines as LPAAT-SS inhibitors and uses thereof LPCAT3, LPCAT1, PLAAT2 CYP46A1 934/4885NR4A2 1402/4885TDP1 3831/4885
US-20250114436-A1 DYNAMIC-COVALENT HYDROGELS WITH GLUCOSE-SPECIFIC AND GLUCOSE-RESPONSIVE DIBORONATE CROSSLINKING IAPP, INSR, GPR119 CYP46A1 3335/4885NR4A2 1928/4885TDP1 3832/4885
US-20030149016-A1 Novel carbapenem derivatives DPEP1, TMPRSS15, STK35 CYP46A1 1849/4885NR4A2 4277/4885TDP1 3544/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.