Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CTSA | P10619 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13793158 | 0.84 | KDM4E (0.46) | KDM4EALOX15TSHRACMSDTDP1 | |
| SCHEMBL2632248 | 0.78 | ALDH1A1 (0.47) | GRM4MAPTCTSAKDM4EALOX15 | |
| SCHEMBL24439792 | 0.78 | GRM4 (0.39) | GRM4MAPTCTSAKDM4EALOX15 | |
| SCHEMBL8281251 | 0.76 | P2RX7 (0.50) | GRM4CTSAKDM4EALOX15TSHR | |
| SCHEMBL21615647 | 0.76 | KDM4E (0.44) | MAPTKDM4EALOX15TSHRACMSD | |
| SCHEMBL13465025 | 0.74 | KDM4E (0.33) | KDM4EALOX15TSHRACMSDTDP1 | |
| SCHEMBL21286483 | 0.74 | KDM4E (0.38) | KDM4EALOX15TSHRACMSDTDP1 | |
| SCHEMBL9368741 | 0.74 | ALDH1A1 (0.42) | MAPTCTSAKDM4EALOX15TSHR | |
| SCHEMBL8282746 | 0.74 | NOS2 (0.46) | GRM4KDM4EALOX15TSHRACMSD | |
| SCHEMBL531659 | 0.74 | GRM5 (0.44) | MAPTCTSAKDM4EALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106117193-A | New Hete rocyclic derivatives and the application in nervous system disease is treated thereof | 诺华股份有限公司 | 2016-11-16 | — | — | CN | disclosed |
| CN-103403001-B | Heterocyclic derivatives and their use in the treatment of neurological disorders | 诺瓦提斯公司 | 2016-08-17 | — | — | CN | disclosed |
| CN-104955805-A | Inhibitors of syk | HOFFMANN LA ROCHE | 2015-09-30 | — | — | CN | disclosed |