Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | PTGIR | P43119 | 1/20 | 0.41 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8469485 | 0.81 | PDE3B (0.45) | GAAAKR1B1CA2PDE3BPDE3A | |
| SCHEMBL15575858 | 0.77 | RXRA (0.39) | GAACA2ALDH1A1RXRACYP26B1 | |
| SCHEMBL15812262 | 0.73 | HTR2C (0.46) | GAAHTR6ALDH1A1HTTCYP26B1 | |
| SCHEMBL13074716 | 0.72 | PKM (1.00) | PKMGAARAPGEF4HSD11B1AKR1B1 | |
| SCHEMBL14486413 | 0.72 | PKM (1.00) | PKMGAARAPGEF4HSD11B1AKR1B1 | |
| SCHEMBL835692 | 0.72 | PKM (1.00) | PKMGAARAPGEF4HSD11B1AKR1B1 | |
| SCHEMBL9336566 | 0.70 | MAPT (0.37) | MEN1KMT2A | |
| SCHEMBL17614163 | 0.68 | PKM (0.52) | PKMGAARAPGEF4HSD11B1CA2 | |
| SCHEMBL10497592 | 0.68 | ALDH1A1 (0.63) | PKMGAARAPGEF4CA2HTR6 | |
| SCHEMBL10828080 | 0.68 | MEN1 (0.46) | GAAALDH1A1HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103492376-B | Bicyclic heterocycle compounds and their uses in therapy | ASTEX THERAPEUTICS LTD | 2015-07-22 | — | — | CN | disclosed |