Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CUL4A | Q13619 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | CASP1 | P29466 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | PRNP | P04156 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28027514 | 0.83 | CUL4A (0.54) | CUL4AKDM4EMEN1KMT2AMAPT | |
| SCHEMBL28026889 | 0.83 | CUL4A (0.54) | CUL4AKDM4EMEN1KMT2AMAPT | |
| SCHEMBL28026887 | 0.83 | KMT2A (0.40) | CUL4AKDM4EMEN1KMT2AMAPT | |
| SCHEMBL28026886 | 0.82 | CUL4A (0.51) | CUL4AKDM4EMEN1KMT2AMAPT | |
| SCHEMBL28026888 | 0.74 | KMT2A (0.43) | CUL4AKDM4EMEN1KMT2AMAPT | |
| SCHEMBL15572874 | 0.73 | MEN1 (0.68) | CUL4AKDM4EMEN1KMT2AMAPT | |
| SCHEMBL28027509 | 0.71 | CUL4A (0.55) | CUL4AKDM4EMEN1KMT2AMAPT | |
| SCHEMBL28026890 | 0.70 | EEF2K (0.56) | CUL4AKDM4EMEN1KMT2AMAPT | |
| SCHEMBL28027503 | 0.68 | CUL4A (0.59) | CUL4A | |
| SCHEMBL22501255 | 0.67 | CA1 (0.53) | KDM4EMAPTTP53RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104968323-A | Inhibitors of CRL4 ubiquitin ligase and uses thereof | UNIV CORNELL | 2015-10-07 | — | — | CN | claimed |
| CN-104968323-A | Inhibitors of CRL4 ubiquitin ligase and uses thereof | UNIV CORNELL | 2015-10-07 | — | — | CN | disclosed |